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Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes Mellitus in Mice

BACKGROUND: Tetrahydrobiopterin is a cofactor of endothelial NO synthase (eNOS), which is critical to embryonic heart development. We aimed to study the effects of sapropterin (Kuvan), an orally active synthetic form of tetrahydrobiopterin on eNOS uncoupling and congenital heart defects (CHDs) induc...

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Detalles Bibliográficos
Autores principales:	Engineer, Anish, Saiyin, Tana, Lu, Xiangru, Kucey, Andrew S., Urquhart, Brad L., Drysdale, Thomas A., Norozi, Kambiz, Feng, Qingping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404194/ https://www.ncbi.nlm.nih.gov/pubmed/30608180 http://dx.doi.org/10.1161/JAHA.118.009624

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