SMAD4 Deficiency Leads to Development of Arteriovenous Malformations in Neonatal and Adult Mice

BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic vascular disorder caused by mutations in endoglin (ENG), activin receptor‐like kinase 1 (ACVRL1;ALK1), or SMAD4. Major clinical symptoms of HHT are arteriovenous malformations (AVMs) found in the brain, lungs, visceral organs,...

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Detalles Bibliográficos
Autores principales: Kim, Yong Hwan, Choe, Se‐woon, Chae, Min‐Young, Hong, Suntaek, Oh, S. Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404197/
https://www.ncbi.nlm.nih.gov/pubmed/30571376
http://dx.doi.org/10.1161/JAHA.118.009514

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