Cargando…

Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction

BACKGROUND: Electrocardiographic (ECG) parameters are regarded as intermediate phenotypes of cardiac arrhythmias. Insight into the genetic underpinnings of these parameters is expected to contribute to the understanding of cardiac arrhythmia mechanisms. Here we used HXB/BXH recombinant inbred rat st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adriaens, Michiel E., Lodder, Elisabeth M., Moreno‐Moral, Aida, Šilhavý, Jan, Heinig, Matthias, Glinge, Charlotte, Belterman, Charly, Wolswinkel, Rianne, Petretto, Enrico, Pravenec, Michal, Remme, Carol Ann, Bezzina, Connie R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404199/ https://www.ncbi.nlm.nih.gov/pubmed/30608189 http://dx.doi.org/10.1161/JAHA.118.009243

Ejemplares similares

Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat
por: Morrissey, Catherine, et al.
Publicado: (2011)

Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction
por: Lodder, Elisabeth M., et al.
Publicado: (2012)

Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a(1798insD/+) mice
por: Rivaud, Mathilde R, et al.
Publicado: (2020)

Genomic approaches for the elucidation of genes and gene networks underlying cardiovascular traits
por: Adriaens, M. E., et al.
Publicado: (2018)

Genome-wide association studies of cardiac electrical phenotypes
por: Glinge, Charlotte, et al.
Publicado: (2020)

Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (I(K,ACh))
por: Veerman, Christiaan C., et al.
Publicado: (2019)

The sodium channel Na(V)1.5 impacts on early murine embryonic cardiac development, structure and function in a non‐electrogenic manner
por: Marchal, Gerard A., et al.
Publicado: (2020)

New Insights into the Genetic Control of Gene Expression using a Bayesian Multi-tissue Approach
por: Petretto, Enrico, et al.
Publicado: (2010)

A Heterozygous Deletion Mutation in the Cardiac Sodium Channel Gene SCN5A with Loss- and Gain-of-Function Characteristics Manifests as Isolated Conduction Disease, without Signs of Brugada or Long QT Syndrome
por: Zumhagen, Sven, et al.
Publicado: (2013)

From integrative genomics to systems genetics in the rat to link genotypes to phenotypes
por: Moreno-Moral, Aida, et al.
Publicado: (2016)

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy
por: Heinig, Matthias, et al.
Publicado: (2017)

Role of active dendritic conductances in subthreshold input integration
por: Remme, Michiel, et al.
Publicado: (2010)

Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension
por: Dahale, Sonal, et al.
Publicado: (2022)

Risk of Sudden Infant Death Syndrome Among Siblings of Children Who Died of Sudden Infant Death Syndrome in Denmark
por: Glinge, Charlotte, et al.
Publicado: (2023)

Multi-tissue Analysis of Co-expression Networks by Higher-Order Generalized Singular Value Decomposition Identifies Functionally Coherent Transcriptional Modules
por: Xiao, Xiaolin, et al.
Publicado: (2014)

Contributions from active dendritic conductances to the Local Field Potential
por: Ness, Torbjørn V, et al.
Publicado: (2015)

Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart
por: Koopmann, Tamara T., et al.
Publicado: (2014)

Active subthreshold dendritic conductances shape the local field potential
por: Ness, Torbjørn V., et al.
Publicado: (2016)

Cardioprotective Regimen of Adaptation to Chronic Hypoxia Diversely Alters Myocardial Gene Expression in SHR and SHR-mt(BN) Conplastic Rat Strains
por: Nedvedova, Iveta, et al.
Publicado: (2019)

Sibling history is associated with heart failure after a first myocardial infarction
por: Glinge, Charlotte, et al.
Publicado: (2020)

Switch From Fetal to Adult SCN5A Isoform in Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Unmasks the Cellular Phenotype of a Conduction Disease–Causing Mutation
por: Veerman, Christiaan C., et al.
Publicado: (2017)

Somatic versus Dendritic Resonance: Differential Filtering of Inputs through Non-Uniform Distributions of Active Conductances
por: Zhuchkova, Ekaterina, et al.
Publicado: (2013)

Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel
por: Lusk, Ryan, et al.
Publicado: (2022)

Correction: Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure
por: Glinge, Charlotte, et al.
Publicado: (2020)

Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure
por: Glinge, Charlotte, et al.
Publicado: (2020)

Downregulation of the Glo1 Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats
por: Šilhavý, Jan, et al.
Publicado: (2020)

Local transmural action potential gradients are absent in the isolated, intact dog heart but present in the corresponding coronary‐perfused wedge
por: Boukens, Bastiaan J., et al.
Publicado: (2017)

Sodium Channel Remodeling in Subcellular Microdomains of Murine Failing Cardiomyocytes
por: Rivaud, Mathilde R., et al.
Publicado: (2017)

Sodium Accumulation and Blood Capillary Rarefaction in the Skin Predispose Spontaneously Hypertensive Rats to Salt Sensitive Hypertension
por: Šilhavý, Jan, et al.
Publicado: (2022)

Translational regulation shapes the molecular landscape of complex disease phenotypes
por: Schafer, Sebastian, et al.
Publicado: (2015)

Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats
por: Liška, František, et al.
Publicado: (2016)

Correction: Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats
por: Liška, František, et al.
Publicado: (2020)

Reduced Sodium Current in the Lateral Ventricular Wall Induces Inferolateral J-Waves
por: Meijborg, Veronique M. F., et al.
Publicado: (2016)

Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model
por: Hüttl, Martina, et al.
Publicado: (2023)

Using Gene Expression to Annotate Cardiovascular GWAS Loci
por: Heinig, Matthias
Publicado: (2018)

Profibrillatory Structural and Functional Properties of the Atrial-Pulmonary Junction in the Absence of Remodeling
por: Gottlieb, Lisa A., et al.
Publicado: (2021)

Bilberries potentially alleviate stress-related retinal gene expression induced by a high-fat diet in mice
por: Mykkänen, Otto T., et al.
Publicado: (2012)

Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose
por: Senko, Anna N., et al.
Publicado: (2022)

Functional Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice
por: Casini, Simona, et al.
Publicado: (2019)

Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery
por: Delahaye-Duriez, Andree, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_bmhi93pjm9ogljmqg6qv9v9kib