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Clinical Correlates of Aortic Stiffness and Wave Amplitude in Black Men and Women in the Community

BACKGROUND: Black individuals have greater risk for cardiovascular disease (CVD) than whites. Identifying CVD risk factors associated with abnormal aortic hemodynamics in blacks may optimize CVD prevention and treatment strategies. METHODS AND RESULTS: Jackson Heart Study participants underwent appl...

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Autores principales: Tsao, Connie W., Washington, Floyd, Musani, Solomon K., Cooper, Leroy L., Tripathi, Avnish, Hamburg, Naomi M., Benjamin, Emelia J., Vasan, Ramachandran S., Mitchell, Gary F., Fox, Ervin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404204/
https://www.ncbi.nlm.nih.gov/pubmed/30608191
http://dx.doi.org/10.1161/JAHA.117.008431
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author Tsao, Connie W.
Washington, Floyd
Musani, Solomon K.
Cooper, Leroy L.
Tripathi, Avnish
Hamburg, Naomi M.
Benjamin, Emelia J.
Vasan, Ramachandran S.
Mitchell, Gary F.
Fox, Ervin R.
author_facet Tsao, Connie W.
Washington, Floyd
Musani, Solomon K.
Cooper, Leroy L.
Tripathi, Avnish
Hamburg, Naomi M.
Benjamin, Emelia J.
Vasan, Ramachandran S.
Mitchell, Gary F.
Fox, Ervin R.
author_sort Tsao, Connie W.
collection PubMed
description BACKGROUND: Black individuals have greater risk for cardiovascular disease (CVD) than whites. Identifying CVD risk factors associated with abnormal aortic hemodynamics in blacks may optimize CVD prevention and treatment strategies. METHODS AND RESULTS: Jackson Heart Study participants underwent applanation tonometry (2011–2016) with assessment of carotid‐femoral pulse wave velocity (CFPWV) and forward wave amplitude (FWA). CVD risk factors were assessed during examination 3 (2009–2012). We examined the association of risk factors with binary and continuous CFPWV and FWA in multivariable stepwise models. We evaluated for effect modification by sex to determine differential associations of risk factors with aortic hemodynamics in men and women. We examined 1322 individuals (mean age 66±11 years, 66% women). Age was strongly associated with elevated CFPWV (odds ratio, 4.76; 95% confidence interval, 3.84–5.89 [P<0.0001]) and FWA (odds ratio, 2.30; 95% CI, 1.98–2.69 [P<0.0001]). Men had greater odds of elevated CFPWV compared with women (odds ratio, 1.54; 95% confidence interval, 1.11–2.13 [P=0.009]). Heart rate, mean arterial pressure, and use of antihypertensive medications were associated with elevated CFPWV and FWA (all P≤0.02). Additionally, total/high‐density lipoprotein cholesterol and fasting glucose were associated with elevated CFPWV (both P≤0.002) and use of diabetes mellitus medications was associated with elevated FWA (P≤0.0001). We observed a steeper association of age and mean arterial pressure with unfavorable aortic hemodynamics in women than men. CONCLUSIONS: In blacks in the community, differential CVD risk factors are associated with aortic stiffness and FWA. Future work may determine the impact of risk factor modification on abnormal central aortic hemodynamics and CVD outcomes.
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spelling pubmed-64042042019-03-18 Clinical Correlates of Aortic Stiffness and Wave Amplitude in Black Men and Women in the Community Tsao, Connie W. Washington, Floyd Musani, Solomon K. Cooper, Leroy L. Tripathi, Avnish Hamburg, Naomi M. Benjamin, Emelia J. Vasan, Ramachandran S. Mitchell, Gary F. Fox, Ervin R. J Am Heart Assoc Original Research BACKGROUND: Black individuals have greater risk for cardiovascular disease (CVD) than whites. Identifying CVD risk factors associated with abnormal aortic hemodynamics in blacks may optimize CVD prevention and treatment strategies. METHODS AND RESULTS: Jackson Heart Study participants underwent applanation tonometry (2011–2016) with assessment of carotid‐femoral pulse wave velocity (CFPWV) and forward wave amplitude (FWA). CVD risk factors were assessed during examination 3 (2009–2012). We examined the association of risk factors with binary and continuous CFPWV and FWA in multivariable stepwise models. We evaluated for effect modification by sex to determine differential associations of risk factors with aortic hemodynamics in men and women. We examined 1322 individuals (mean age 66±11 years, 66% women). Age was strongly associated with elevated CFPWV (odds ratio, 4.76; 95% confidence interval, 3.84–5.89 [P<0.0001]) and FWA (odds ratio, 2.30; 95% CI, 1.98–2.69 [P<0.0001]). Men had greater odds of elevated CFPWV compared with women (odds ratio, 1.54; 95% confidence interval, 1.11–2.13 [P=0.009]). Heart rate, mean arterial pressure, and use of antihypertensive medications were associated with elevated CFPWV and FWA (all P≤0.02). Additionally, total/high‐density lipoprotein cholesterol and fasting glucose were associated with elevated CFPWV (both P≤0.002) and use of diabetes mellitus medications was associated with elevated FWA (P≤0.0001). We observed a steeper association of age and mean arterial pressure with unfavorable aortic hemodynamics in women than men. CONCLUSIONS: In blacks in the community, differential CVD risk factors are associated with aortic stiffness and FWA. Future work may determine the impact of risk factor modification on abnormal central aortic hemodynamics and CVD outcomes. John Wiley and Sons Inc. 2018-10-23 /pmc/articles/PMC6404204/ /pubmed/30608191 http://dx.doi.org/10.1161/JAHA.117.008431 Text en © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Tsao, Connie W.
Washington, Floyd
Musani, Solomon K.
Cooper, Leroy L.
Tripathi, Avnish
Hamburg, Naomi M.
Benjamin, Emelia J.
Vasan, Ramachandran S.
Mitchell, Gary F.
Fox, Ervin R.
Clinical Correlates of Aortic Stiffness and Wave Amplitude in Black Men and Women in the Community
title Clinical Correlates of Aortic Stiffness and Wave Amplitude in Black Men and Women in the Community
title_full Clinical Correlates of Aortic Stiffness and Wave Amplitude in Black Men and Women in the Community
title_fullStr Clinical Correlates of Aortic Stiffness and Wave Amplitude in Black Men and Women in the Community
title_full_unstemmed Clinical Correlates of Aortic Stiffness and Wave Amplitude in Black Men and Women in the Community
title_short Clinical Correlates of Aortic Stiffness and Wave Amplitude in Black Men and Women in the Community
title_sort clinical correlates of aortic stiffness and wave amplitude in black men and women in the community
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404204/
https://www.ncbi.nlm.nih.gov/pubmed/30608191
http://dx.doi.org/10.1161/JAHA.117.008431
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