Cargando…

Regenerative cell therapy for pulmonary arterial hypertension in animal models: a systematic review

BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare disease characterized by widespread loss of the pulmonary microcirculation and elevated pulmonary arterial pressures leading to pathological right ventricular remodeling and ultimately right heart failure. Regenerative cell therapies could...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suen, Colin M., Stewart, Duncan J., Montroy, Joshua, Welsh, Christopher, Levac, Brendan, Wesch, Neil, Zhai, Alexander, Fergusson, Dean, McIntyre, Lauralyn, Lalu, Manoj M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404277/ https://www.ncbi.nlm.nih.gov/pubmed/30841915 http://dx.doi.org/10.1186/s13287-019-1172-6

Ejemplares similares

Efficacy and safety of regenerative cell therapy for pulmonary arterial hypertension in animal models: a preclinical systematic review protocol
por: Suen, Colin M., et al.
Publicado: (2016)

Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials
por: Lalu, Manoj M., et al.
Publicado: (2012)

Methods and efficacy of extracellular vesicles derived from mesenchymal stromal cells in animal models of disease: a preclinical systematic review protocol
por: Tieu, Alvin, et al.
Publicado: (2019)

Safety and Efficacy of Adult Stem Cell Therapy for Acute Myocardial Infarction and Ischemic Heart Failure (SafeCell Heart): A Systematic Review and Meta‐Analysis
por: Lalu, Manoj M., et al.
Publicado: (2018)

Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol
por: Barron, Carly C., et al.
Publicado: (2017)

The Devil Is in the Details: Incomplete Reporting in Preclinical Animal Research
por: Avey, Marc T., et al.
Publicado: (2016)

Mesenchymal stromal cell extracellular vesicles as therapy for acute and chronic respiratory diseases: A meta‐analysis
por: Tieu, Alvin, et al.
Publicado: (2021)

Identifying and understanding factors that affect the translation of therapies from the laboratory to patients: a study protocol
por: Lalu, Manoj M., et al.
Publicado: (2020)

Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review
por: McIntyre, Lauralyn A., et al.
Publicado: (2016)

A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies
por: Hunniford, Victoria T, et al.
Publicado: (2023)

Mapping the preclinical to clinical evidence and development trajectory of the oncolytic virus talimogene laherparepvec (T-VEC): a systematic review
por: Lalu, Manoj, et al.
Publicado: (2019)

The effects of resistant starches on inflammatory bowel disease in preclinical and clinical settings: a systematic review and meta-analysis
por: Montroy, Joshua, et al.
Publicado: (2020)

Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial
por: Lalu, Manoj M, et al.
Publicado: (2016)

Efficacy and safety of mesenchymal stromal cells in preclinical models of acute lung injury: a systematic review protocol
por: Lalu, Manoj M, et al.
Publicado: (2014)

A survey of Canadian intensivists' resuscitation practices in early septic shock
por: McIntyre, Lauralyn A, et al.
Publicado: (2007)

Safety and efficacy of autologous tumour cell vaccines as a cancer therapeutic to treat solid tumours and haematological malignancies: a meta-analysis protocol for two systematic reviews
por: Khan, Sarwat T, et al.
Publicado: (2020)

Lack of elevation in plasma levels of pro-inflammatory cytokines in common rodent models of pulmonary arterial hypertension: questions of construct validity for human patients
por: Schlosser, Kenny, et al.
Publicado: (2017)

Cell therapy with intravascular administration of mesenchymal stromal cells continues to appear safe: An updated systematic review and meta-analysis
por: Thompson, Mary, et al.
Publicado: (2020)

Customized Internal Reference Controls for Improved Assessment of Circulating MicroRNAs in Disease
por: Schlosser, Kenny, et al.
Publicado: (2015)

Safety and Efficacy of Adeno-Associated Viral Gene Therapy in Patients With Retinal Degeneration: A Systematic Review and Meta-Analysis
por: Sobh, Mohamad, et al.
Publicado: (2023)

Red blood cell transfusion and mortality effect in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis protocol
por: English, Shane W, et al.
Publicado: (2015)

Hematologists’ barriers and enablers to screening and recruiting patients to a chimeric antigen receptor (CAR) T cell therapy trial: a theory-informed interview study
por: Castillo, Gisell, et al.
Publicado: (2021)

Thawed Mesenchymal Stem Cell Product Shows Comparable Immunomodulatory Potency to Cultured Cells In Vitro and in Polymicrobial Septic Animals
por: Tan, Yuan, et al.
Publicado: (2019)

A call to implement preclinical study registration in animal ethics review
por: Jeffers, Matthew S., et al.
Publicado: (2023)

Identifying barriers and enablers to rigorous conduct and reporting of preclinical laboratory studies
por: Lalu, Manoj M., et al.
Publicado: (2023)

Identifying effect modifiers of CAR-T cell therapeutic efficacy: a systematic review and individual patient data meta-analysis protocol
por: Lalu, Manoj M., et al.
Publicado: (2023)

The conundrum of persistent inappropriate use of frozen plasma
por: Tinmouth, Alan T, et al.
Publicado: (2011)

The Effects of Biological Sex on Sepsis Treatments in Animal Models: A Systematic Review and a Narrative Elaboration on Sex- and Gender-Dependent Differences in Sepsis
por: Zhang, MengQi, et al.
Publicado: (2021)

Renal outcomes and mortality following hydroxyethyl starch resuscitation of critically ill patients: systematic review and meta-analysis of randomized trials: ATTENTION: The analysis and conclusions of this article are being revised by the authors. This is due to the journal Anesthesia and Analgesia's retraction of a paper by Dr. Joachim Boldt, an author in seven of the studies analyzed in this review. As such, the editors of Open Medicine recommend interpreting this review with extreme caution until Zarychanski et al. publish a new analysis and interpretation in Open Medicine. For more information, see Anesthesia and Analgesia's press release.
por: Zarychanski, Ryan, et al.
Publicado: (2009)

Comparison of crystalloid resuscitation fluids for treatment of acute brain injury: a clinical and pre-clinical systematic review and network meta-analysis protocol
por: Thompson, Mary, et al.
Publicado: (2018)

Navigating choice in the face of uncertainty: using a theory informed qualitative approach to identifying potential patient barriers and enablers to participating in an early phase chimeric antigen receptor T (CAR-T) cell therapy trial
por: Castillo, Gisell, et al.
Publicado: (2021)

Vitamin D deficiency in critically ill children: a systematic review and meta-analysis
por: McNally, James Dayre, et al.
Publicado: (2017)

Transfusion of red blood cells in patients with traumatic brain injuries admitted to Canadian trauma health centres: a multicentre cohort study
por: Boutin, Amélie, et al.
Publicado: (2017)

Assessment of Circulating LncRNAs Under Physiologic and Pathologic Conditions in Humans Reveals Potential Limitations as Biomarkers
por: Schlosser, Kenny, et al.
Publicado: (2016)

High circulating angiopoietin-2 levels exacerbate pulmonary inflammation but not vascular leak or mortality in endotoxin-induced lung injury in mice
por: Schlosser, Kenny, et al.
Publicado: (2018)

Partnering with patients to get better outcomes with chimeric antigen receptor T-cell therapy: towards engagement of patients in early phase trials
por: Foster, Madison, et al.
Publicado: (2020)

Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients*
por: Schlosser, Kenny, et al.
Publicado: (2019)

Effect of blood donor characteristics on transfusion outcomes: a protocol for systematic review and meta-analysis
por: Chassé, Michaël, et al.
Publicado: (2014)

A Scoping Review of Registered Clinical Trials of Cellular Therapy for COVID-19 and a Framework for Accelerated Synthesis of Trial Evidence—FAST Evidence
por: Liao, Gary, et al.
Publicado: (2020)

Airway recommendations for perioperative patients during the COVID-19 pandemic: a scoping review
por: Grudzinski, Alexa Lynn, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_aa9v5aqhkkhqic8otaklapl6hr