What causes severe malaria and its complications in children? Lessons learned over the past 15 years

Over the past 15 years, malaria mortality has reduced by approximately 50%. However, malaria still causes more than 400,000 deaths annually, most of which occur in African children under 5 years of age. Significant advances in understanding the pathogenesis of the disease provide a basis for future...

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Detalles Bibliográficos
Autores principales: Conroy, Andrea L., Datta, Dibyadyuti, John, Chandy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404293/
https://www.ncbi.nlm.nih.gov/pubmed/30841892
http://dx.doi.org/10.1186/s12916-019-1291-z
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author Conroy, Andrea L.
Datta, Dibyadyuti
John, Chandy C.
author_facet Conroy, Andrea L.
Datta, Dibyadyuti
John, Chandy C.
author_sort Conroy, Andrea L.
collection PubMed
description Over the past 15 years, malaria mortality has reduced by approximately 50%. However, malaria still causes more than 400,000 deaths annually, most of which occur in African children under 5 years of age. Significant advances in understanding the pathogenesis of the disease provide a basis for future work to prevent severe malaria and its complications. Herein, we provide an overview of advances in our understanding of severe malaria in African children over the past 15 years, highlighting key complications and identifying priorities to further reduce malaria-associated mortality.
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spelling pubmed-64042932019-03-18 What causes severe malaria and its complications in children? Lessons learned over the past 15 years Conroy, Andrea L. Datta, Dibyadyuti John, Chandy C. BMC Med Correspondence Over the past 15 years, malaria mortality has reduced by approximately 50%. However, malaria still causes more than 400,000 deaths annually, most of which occur in African children under 5 years of age. Significant advances in understanding the pathogenesis of the disease provide a basis for future work to prevent severe malaria and its complications. Herein, we provide an overview of advances in our understanding of severe malaria in African children over the past 15 years, highlighting key complications and identifying priorities to further reduce malaria-associated mortality. BioMed Central 2019-03-07 /pmc/articles/PMC6404293/ /pubmed/30841892 http://dx.doi.org/10.1186/s12916-019-1291-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Correspondence
Conroy, Andrea L.
Datta, Dibyadyuti
John, Chandy C.
What causes severe malaria and its complications in children? Lessons learned over the past 15 years
title What causes severe malaria and its complications in children? Lessons learned over the past 15 years
title_full What causes severe malaria and its complications in children? Lessons learned over the past 15 years
title_fullStr What causes severe malaria and its complications in children? Lessons learned over the past 15 years
title_full_unstemmed What causes severe malaria and its complications in children? Lessons learned over the past 15 years
title_short What causes severe malaria and its complications in children? Lessons learned over the past 15 years
title_sort what causes severe malaria and its complications in children? lessons learned over the past 15 years
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404293/
https://www.ncbi.nlm.nih.gov/pubmed/30841892
http://dx.doi.org/10.1186/s12916-019-1291-z
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