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Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

Internal ribosome entry site (IRES) sequences have become a valuable tool in the construction of gene transfer and therapeutic vectors for multi-cistronic gene expression from a single mRNA transcript. The optimal conditions for effective use of this sequence to construct a functional expression vec...

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Detalles Bibliográficos
Autores principales:	Al-Allaf, Faisal A., Abduljaleel, Zainularifeen, Athar, Mohammad, Taher, Mohiuddin M., Khan, Wajahatullah, Mehmet, Huseyin, Colakogullari, Mukaddes, Apostolidou, Sophia, Bigger, Brian, Waddington, Simon, Coutelle, Charles, Themis, Michael, Al-Ahdal, Mohammed N., Al-Mohanna, Futwan A., Al-Hassnan, Zuhair N., Bouazzaoui, Abdellatif
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	KeAi Publishing 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404380/ https://www.ncbi.nlm.nih.gov/pubmed/30891532 http://dx.doi.org/10.1016/j.ncrna.2018.11.005

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