Synthesis and biological investigation of (+)-3-hydroxymethylartemisinin

Herein, we describe a biomimetic entry to (+)-3-hydroxymethylartemisinin (2) as well as to the artemisinin derivatives (+)-3-hydroxymethyl-9-desmethylartemisinin (16) and (+)-3-hydroxymethyl-9-epi-artemisinin (18), starting from the known and readily available chiral aldehyde 3 and alkyne 4. Subsequ...

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Detalles Bibliográficos
Autores principales: Smeilus, Toni, Mousavizadeh, Farnoush, Krieger, Johannes, Tu, Xingzhao, Kaiser, Marcel, Giannis, Athanassios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2019
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404461/
https://www.ncbi.nlm.nih.gov/pubmed/30873241
http://dx.doi.org/10.3762/bjoc.15.51

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404461/
https://www.ncbi.nlm.nih.gov/pubmed/30873241
http://dx.doi.org/10.3762/bjoc.15.51

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