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Synthesis and biological investigation of (+)-3-hydroxymethylartemisinin
Herein, we describe a biomimetic entry to (+)-3-hydroxymethylartemisinin (2) as well as to the artemisinin derivatives (+)-3-hydroxymethyl-9-desmethylartemisinin (16) and (+)-3-hydroxymethyl-9-epi-artemisinin (18), starting from the known and readily available chiral aldehyde 3 and alkyne 4. Subsequ...
Autores principales: | Smeilus, Toni, Mousavizadeh, Farnoush, Krieger, Johannes, Tu, Xingzhao, Kaiser, Marcel, Giannis, Athanassios |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404461/ https://www.ncbi.nlm.nih.gov/pubmed/30873241 http://dx.doi.org/10.3762/bjoc.15.51 |
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