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Inhibition of α5 GABAA receptors has preventive but not therapeutic effects on isoflurane-induced memory impairment in aged rats
The α5 subunit-containing gamma-amino butyric acid type A receptors (α5 GABAARs) are a distinct subpopulation that are specifically distributed in the mammalian hippocampus and also mediate tonic inhibitory currents in hippocampal neurons. These tonic currents can be enhanced by low-dose isoflurane,...
Autores principales: | Zhao, Zi-Fang, Du, Lei, Gao, Teng, Bao, Lin, Luo, Yuan, Yin, Yi-Qing, Wang, Yong-An |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404482/ https://www.ncbi.nlm.nih.gov/pubmed/30762015 http://dx.doi.org/10.4103/1673-5374.250621 |
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