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Rapid transport of insulin to the brain following intranasal administration in rats

We previously reported that intranasal insulin protects substantia nigra dopaminergic neurons against 6-hydroxydopamine neurotoxicity in rats. This study aimed to assess insulin pharmacokinetics in the rat brain following intranasal application. Recombinant human insulin (rh-Ins) or phosphate buffer...

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Detalles Bibliográficos
Autores principales: Fan, Lir-Wan, Carter, Kathleen, Bhatt, Abhay, Pang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404510/
https://www.ncbi.nlm.nih.gov/pubmed/30762017
http://dx.doi.org/10.4103/1673-5374.250624