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TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia

BACKGROUND: Mutations in the three‐prime repair exonuclease 1 (TREX1) gene have been associated with neurological diseases, including Retinal Vasculopathy with Cerebral Leukoencephalopathy (RVCL). However, the endogenous expression of TREX1 in human brain has not been studied. METHODS: We produced a...

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Detalles Bibliográficos
Autores principales: Kothari, Parul H., Kolar, Grant R., Jen, Joanna C., Hajj‐Ali, Rula, Bertram, Paula, Schmidt, Robert E., Atkinson, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404532/
https://www.ncbi.nlm.nih.gov/pubmed/30062819
http://dx.doi.org/10.1111/bpa.12626

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