Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

Mutations in more than 80 different positions in superoxide dismutase 1 (SOD1) have been associated with amyotrophic lateral sclerosis (fALS). There is substantial evidence that a common consequence of these mutations is to induce the protein to misfold and aggregate. How these mutations perturb nat...

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Detalles Bibliográficos
Autores principales: Crown, Anthony M., Roberts, Brittany L., Crosby, Keith, Brown, Hilda, Ayers, Jacob I., Hart, P. John, Borchelt, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2019
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404617/
https://www.ncbi.nlm.nih.gov/pubmed/30622123
http://dx.doi.org/10.1534/g3.118.200787

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