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Achieving High-Yield Production of Functional AAV5 Gene Delivery Vectors via Fedbatch in an Insect Cell-One Baculovirus System
Despite numerous advancements in production protocols, manufacturing AAV to meet exceptionally high demand (10(16)–10(17) viral genomes [VGs]) in late clinical stages and for eventual systemic delivery poses significant challenges. Here, we report an efficient, simple, scalable, robust AAV5 producti...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404649/ https://www.ncbi.nlm.nih.gov/pubmed/30886878 http://dx.doi.org/10.1016/j.omtm.2019.02.003 |