CRISPR‐Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias

BACKGROUND: The sodium channel, Na(v)1.5, encoded by SCN5A, undergoes developmentally regulated splicing from inclusion of exon 6A in the fetal heart to exon 6B in adults. These mutually exclusive exons differ in 7 amino acids altering the electrophysiological properties of the Na(v)1.5 channel. In...

Descripción completa

Detalles Bibliográficos
Autores principales: Pang, Paul D., Alsina, Katherina M., Cao, Shuyi, Koushik, Amrita B., Wehrens, Xander H.T., Cooper, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404881/
https://www.ncbi.nlm.nih.gov/pubmed/30371314
http://dx.doi.org/10.1161/JAHA.118.010393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404881/
https://www.ncbi.nlm.nih.gov/pubmed/30371314
http://dx.doi.org/10.1161/JAHA.118.010393

Ejemplares similares