Cargando…

CRISPR‐Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias

BACKGROUND: The sodium channel, Na(v)1.5, encoded by SCN5A, undergoes developmentally regulated splicing from inclusion of exon 6A in the fetal heart to exon 6B in adults. These mutually exclusive exons differ in 7 amino acids altering the electrophysiological properties of the Na(v)1.5 channel. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pang, Paul D., Alsina, Katherina M., Cao, Shuyi, Koushik, Amrita B., Wehrens, Xander H.T., Cooper, Thomas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404881/ https://www.ncbi.nlm.nih.gov/pubmed/30371314 http://dx.doi.org/10.1161/JAHA.118.010393

Ejemplares similares

Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform
por: Wang, Tiannan, et al.
Publicado: (2011)

Unraveling the Mechanisms by Which Calpain Inhibition Prevents Heart Failure Development
por: Wehrens, Xander H.T.
Publicado: (2018)

Genome Editing and Cardiac Arrhythmias
por: Moore, Oliver M., et al.
Publicado: (2023)

Refractory dispersion promotes conduction disturbance and arrhythmias in a Scn5a(+/−) mouse model
por: Martin, Claire A., et al.
Publicado: (2011)

Transthoracic Echocardiography in Mice
por: Respress, Jonathan L., et al.
Publicado: (2010)

Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy
por: Freyermuth, Fernande, et al.
Publicado: (2016)

RBFOX2 regulated EYA3 isoforms partner with SIX4 or ZBTB1 to control transcription during myogenesis
por: Wiedner, Hannah J., et al.
Publicado: (2023)

Ambulatory ECG Recording in Mice
por: McCauley, Mark D., et al.
Publicado: (2010)

Mouse Models of SCN5A-Related Cardiac Arrhythmias
por: Derangeon, Mickael, et al.
Publicado: (2012)

Switch From Fetal to Adult SCN5A Isoform in Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Unmasks the Cellular Phenotype of a Conduction Disease–Causing Mutation
por: Veerman, Christiaan C., et al.
Publicado: (2017)

Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes
por: Yagihara, Nobue, et al.
Publicado: (2016)

Treatment of Fetal Arrhythmias
por: Veduta, Alina, et al.
Publicado: (2021)

E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice
por: Carll, Alex P., et al.
Publicado: (2022)

Reversible cardiac disease features in an inducible CUG repeat RNA–expressing mouse model of myotonic dystrophy
por: Rao, Ashish N., et al.
Publicado: (2021)

Fetal arrhythmias: Diagnosis and management
por: Batra, Anjan S., et al.
Publicado: (2019)

Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a(+/−) hearts
por: Matthews, Gareth D K, et al.
Publicado: (2013)

Genetic analysis of cardiac SCN5A Gene in Iranian patients with hereditary cardiac arrhythmias
por: Asadi, Marzi, et al.
Publicado: (2016)

SCN5A Variants as Genetic Arrhythmias Triggers for Familial Bileaflet Mitral Valve Prolapse
por: Jaouadi, Hager, et al.
Publicado: (2022)

Cardiac conduction defects and Brugada syndrome: A family with overlap syndrome carrying a nonsense SCN5A mutation()
por: Aoki, Hisaaki, et al.
Publicado: (2017)

The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy
por: Salvarani, Nicolò, et al.
Publicado: (2019)

Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na(+)-channel-blocking antiepileptic drugs
por: Herrera, José A., et al.
Publicado: (2015)

Fetal cardiac arrhythmias: Current evidence
por: Bravo-Valenzuela, Nathalie Jeanne, et al.
Publicado: (2018)

Fetal Arrhythmia Diagnosis and Pharmacologic Management
por: Strasburger, Janette F., et al.
Publicado: (2022)

Facile Synthesis of Colored and Conducting CuSCN Composite Coated with CuS Nanoparticles
por: Premalal, E. V. A., et al.
Publicado: (2017)

Influence of Generated Defects by Ar Implantation on the Thermoelectric Properties of ScN
por: Burcea, Razvan, et al.
Publicado: (2022)

Further Insights in the Most Common SCN5A Mutation Causing Overlapping Phenotype of Long QT Syndrome, Brugada Syndrome, and Conduction Defect
por: Veltmann, Christian, et al.
Publicado: (2016)

Contribution of Fetal Magnetocardiography to Diagnosis, Risk Assessment, and Treatment of Fetal Arrhythmia
por: Wacker‐Gussmann, Annette, et al.
Publicado: (2022)

Drug Resistant Fetal Arrhythmia in Obstetric Cholestasis
por: Altug, Nahide, et al.
Publicado: (2015)

Erratum: Fetal cardiac arrhythmias: Current evidence
Publicado: (2018)

Fetal arrhythmias: prenatal evaluation and intrauterine therapeutics
por: Yuan, Shi-Min, et al.
Publicado: (2020)

Abnormalities in cardiac and inflammatory biomarkers in ambulatory subjects after COVID-19 infection
por: Keefe, Joshua A., et al.
Publicado: (2022)

The role of junctophilin proteins in cellular function
por: Lehnart, Stephan E., et al.
Publicado: (2022)

Genetic Analysis of SCN5A in Korean Patients Associated with Atrioventricular Conduction Block
por: Park, Hyoung Seob, et al.
Publicado: (2012)

Correction to Influence of Generated Defects by Ar Implantation on the Thermoelectric Properties of ScN
por: Burcea, Razvan, et al.
Publicado: (2023)

Management of cardiac conduction abnormalities and arrhythmia in aircrew
por: Guettler, Norbert, et al.
Publicado: (2019)

Arrhythmias and Conduction Disturbances in Autoimmune Rheumatic Disorders
por: Plastiras, Sotiris C, et al.
Publicado: (2021)

Emergency therapy of maternal and fetal arrhythmias during pregnancy
por: Trappe, Hans-Joachim
Publicado: (2010)

Fetal arrhythmias: Ten years’ experience and review of the literature
por: Ekici, Hüseyin, et al.
Publicado: (2022)

Reduced Na(+) and higher K(+) channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/− mice
por: Martin, Claire A., et al.
Publicado: (2012)

Biophysical Characterization of a Novel SCN5A Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death
por: Ghovanloo, Mohammad-Reza, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_72mtpcgkqjqseqvtedhueauel9