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The Design and Analysis of Seroefficacy Studies for Typhoid Conjugate Vaccines

BACKGROUND: Demonstrating the efficacy of new Vi-conjugate typhoid vaccines is challenging, due to the cost of field trials requiring tens of thousands of participants. New trial designs that use serologically defined typhoid infections (seroefficacy trials) rather than blood culture positivity as a...

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Detalles Bibliográficos
Autores principales:	Liu, Xinxue, Pitzer, Virginia E, Pollard, Andrew J, Voysey, Merryn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Supplement Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405265/ https://www.ncbi.nlm.nih.gov/pubmed/30845326 http://dx.doi.org/10.1093/cid/ciy1119

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