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A Review of the Economic Evidence of Typhoid Fever and Typhoid Vaccines

Typhoid places a substantial economic burden on low- and middle-income countries. We performed a literature review and critical overview of typhoid-related economic issues to inform vaccine introduction. We searched 4 literature databases, covering 2000–2017, to identify typhoid-related cost-of-illn...

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Autores principales: Luthra, K, Watts, E, Debellut, F, Pecenka, C, Bar-Zeev, N, Constenla, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405266/
https://www.ncbi.nlm.nih.gov/pubmed/30845334
http://dx.doi.org/10.1093/cid/ciy1122
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author Luthra, K
Watts, E
Debellut, F
Pecenka, C
Bar-Zeev, N
Constenla, D
author_facet Luthra, K
Watts, E
Debellut, F
Pecenka, C
Bar-Zeev, N
Constenla, D
author_sort Luthra, K
collection PubMed
description Typhoid places a substantial economic burden on low- and middle-income countries. We performed a literature review and critical overview of typhoid-related economic issues to inform vaccine introduction. We searched 4 literature databases, covering 2000–2017, to identify typhoid-related cost-of-illness (COI) studies, cost-of-delivery studies, cost-effectiveness analyses (CEAs), and demand forecast studies. Manual bibliographic searches of reviews revealed studies in the gray literature. Planned studies were identified in conference proceedings and through partner organization outreach. We identified 29 published, unpublished, and planned studies. Published COI studies revealed a substantial burden in Asia, with hospitalization costs alone ranging from $159 to $636 (in 2016 US$) in India, but there was less evidence for the burden in Africa. Cost-of-delivery studies are largely unpublished, but 1 study found that $671 000 in government investments would avert $60 000 in public treatment costs. CEA evidence was limited, but generally found targeted vaccination programs to be cost-effective. This review revealed insufficient economic evidence for vaccine introduction. Countries considering vaccine introduction should have access to relevant economic evidence to aid in decision-making and planning. Planned studies will fill many of the existing gaps in the literature.
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spelling pubmed-64052662019-03-12 A Review of the Economic Evidence of Typhoid Fever and Typhoid Vaccines Luthra, K Watts, E Debellut, F Pecenka, C Bar-Zeev, N Constenla, D Clin Infect Dis Supplement Articles Typhoid places a substantial economic burden on low- and middle-income countries. We performed a literature review and critical overview of typhoid-related economic issues to inform vaccine introduction. We searched 4 literature databases, covering 2000–2017, to identify typhoid-related cost-of-illness (COI) studies, cost-of-delivery studies, cost-effectiveness analyses (CEAs), and demand forecast studies. Manual bibliographic searches of reviews revealed studies in the gray literature. Planned studies were identified in conference proceedings and through partner organization outreach. We identified 29 published, unpublished, and planned studies. Published COI studies revealed a substantial burden in Asia, with hospitalization costs alone ranging from $159 to $636 (in 2016 US$) in India, but there was less evidence for the burden in Africa. Cost-of-delivery studies are largely unpublished, but 1 study found that $671 000 in government investments would avert $60 000 in public treatment costs. CEA evidence was limited, but generally found targeted vaccination programs to be cost-effective. This review revealed insufficient economic evidence for vaccine introduction. Countries considering vaccine introduction should have access to relevant economic evidence to aid in decision-making and planning. Planned studies will fill many of the existing gaps in the literature. Oxford University Press 2019-03-15 2019-03-07 /pmc/articles/PMC6405266/ /pubmed/30845334 http://dx.doi.org/10.1093/cid/ciy1122 Text en © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Supplement Articles
Luthra, K
Watts, E
Debellut, F
Pecenka, C
Bar-Zeev, N
Constenla, D
A Review of the Economic Evidence of Typhoid Fever and Typhoid Vaccines
title A Review of the Economic Evidence of Typhoid Fever and Typhoid Vaccines
title_full A Review of the Economic Evidence of Typhoid Fever and Typhoid Vaccines
title_fullStr A Review of the Economic Evidence of Typhoid Fever and Typhoid Vaccines
title_full_unstemmed A Review of the Economic Evidence of Typhoid Fever and Typhoid Vaccines
title_short A Review of the Economic Evidence of Typhoid Fever and Typhoid Vaccines
title_sort review of the economic evidence of typhoid fever and typhoid vaccines
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405266/
https://www.ncbi.nlm.nih.gov/pubmed/30845334
http://dx.doi.org/10.1093/cid/ciy1122
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