Downregulating Notch counteracts Kras(G12D)-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm

The Notch signaling pathway contributes to the pathogenesis of a wide spectrum of human cancers, including hematopoietic malignancies. Its functions are highly dependent on the specific cellular context. Gain-of-function NOTCH1 mutations are prevalent in human T cell leukemia, while loss of Notch si...

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Detalles Bibliográficos
Autores principales: Kong, Guangyao, You, Xiaona, Wen, Zhi, Chang, Yuan-I, Qian, Shuiming, Ranheim, Erik A., Letson, Christopher, Zhang, Xinmin, Zhou, Yun, Liu, Yangang, Rajagopalan, Adhithi, Zhang, Jingfang, Hofmann-Zhang, Inga, Zhong, Xuehua, Padron, Eric, Zhou, Lan, Pear, Warren S., Zhang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405304/
https://www.ncbi.nlm.nih.gov/pubmed/30206308
http://dx.doi.org/10.1038/s41375-018-0248-0

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