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Breakdown of Autonomously Functioning Thyroid Nodule Accompanied by Acromegaly After Octreotide Treatment
Patients with acromegaly are at increased risk of developing certain tumors, including goiter and thyroid nodules, and occasionally autonomous thyroid nodules. A 53-year-old woman presented at our hospital with untreated acromegaly. She had typical physical features of acromegaly with pituitary aden...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405443/ https://www.ncbi.nlm.nih.gov/pubmed/30881346 http://dx.doi.org/10.3389/fendo.2019.00131 |
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author | Nomoto, Hiroshi Kameda, Hiraku Nakamura, Akinobu Tsuchida, Kazuhisa Nagai, So Atsumi, Tatsuya Miyoshi, Hideaki |
author_facet | Nomoto, Hiroshi Kameda, Hiraku Nakamura, Akinobu Tsuchida, Kazuhisa Nagai, So Atsumi, Tatsuya Miyoshi, Hideaki |
author_sort | Nomoto, Hiroshi |
collection | PubMed |
description | Patients with acromegaly are at increased risk of developing certain tumors, including goiter and thyroid nodules, and occasionally autonomous thyroid nodules. A 53-year-old woman presented at our hospital with untreated acromegaly. She had typical physical features of acromegaly with pituitary adenoma, and thyrotoxicosis with thyroid-stimulating hormone suppression was also confirmed. Thyroid ultrasonography and scintigraphy showed an autonomously functioning thyroid nodule on her right lobe. Because her thyrotoxicosis was mild, she was initially treated with octreotide for acromegaly. However, 1 month after octreotide administration, she developed neck pain and fever with transient thyrotoxicosis. The blood flow around the nodule then decreased and the excess trapping of isotope detected by scintigraphy was reduced, followed by normalization of insulin-like growth factor-1 levels and thyroid function. This case suggests that octreotide may have unexpected effects on autonomous thyroid nodules. However, further studies are needed to determine the clinical course of autonomously functioning thyroid nodules, including thyroid function and tumor manifestations, during octreotide therapy. |
format | Online Article Text |
id | pubmed-6405443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64054432019-03-15 Breakdown of Autonomously Functioning Thyroid Nodule Accompanied by Acromegaly After Octreotide Treatment Nomoto, Hiroshi Kameda, Hiraku Nakamura, Akinobu Tsuchida, Kazuhisa Nagai, So Atsumi, Tatsuya Miyoshi, Hideaki Front Endocrinol (Lausanne) Endocrinology Patients with acromegaly are at increased risk of developing certain tumors, including goiter and thyroid nodules, and occasionally autonomous thyroid nodules. A 53-year-old woman presented at our hospital with untreated acromegaly. She had typical physical features of acromegaly with pituitary adenoma, and thyrotoxicosis with thyroid-stimulating hormone suppression was also confirmed. Thyroid ultrasonography and scintigraphy showed an autonomously functioning thyroid nodule on her right lobe. Because her thyrotoxicosis was mild, she was initially treated with octreotide for acromegaly. However, 1 month after octreotide administration, she developed neck pain and fever with transient thyrotoxicosis. The blood flow around the nodule then decreased and the excess trapping of isotope detected by scintigraphy was reduced, followed by normalization of insulin-like growth factor-1 levels and thyroid function. This case suggests that octreotide may have unexpected effects on autonomous thyroid nodules. However, further studies are needed to determine the clinical course of autonomously functioning thyroid nodules, including thyroid function and tumor manifestations, during octreotide therapy. Frontiers Media S.A. 2019-03-01 /pmc/articles/PMC6405443/ /pubmed/30881346 http://dx.doi.org/10.3389/fendo.2019.00131 Text en Copyright © 2019 Nomoto, Kameda, Nakamura, Tsuchida, Nagai, Atsumi and Miyoshi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Nomoto, Hiroshi Kameda, Hiraku Nakamura, Akinobu Tsuchida, Kazuhisa Nagai, So Atsumi, Tatsuya Miyoshi, Hideaki Breakdown of Autonomously Functioning Thyroid Nodule Accompanied by Acromegaly After Octreotide Treatment |
title | Breakdown of Autonomously Functioning Thyroid Nodule Accompanied by Acromegaly After Octreotide Treatment |
title_full | Breakdown of Autonomously Functioning Thyroid Nodule Accompanied by Acromegaly After Octreotide Treatment |
title_fullStr | Breakdown of Autonomously Functioning Thyroid Nodule Accompanied by Acromegaly After Octreotide Treatment |
title_full_unstemmed | Breakdown of Autonomously Functioning Thyroid Nodule Accompanied by Acromegaly After Octreotide Treatment |
title_short | Breakdown of Autonomously Functioning Thyroid Nodule Accompanied by Acromegaly After Octreotide Treatment |
title_sort | breakdown of autonomously functioning thyroid nodule accompanied by acromegaly after octreotide treatment |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405443/ https://www.ncbi.nlm.nih.gov/pubmed/30881346 http://dx.doi.org/10.3389/fendo.2019.00131 |
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