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Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell–Derived Cells: Universal Donor for Cell Therapy

BACKGROUND: We aim to generate a line of “universal donor” human induced pluripotent stem cells (hiPSCs) that are nonimmunogenic and, therefore, can be used to derive cell products suitable for allogeneic transplantation. METHODS AND RESULTS: hiPSCs carrying knockout mutations for 2 key components (...

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Detalles Bibliográficos
Autores principales:	Mattapally, Saidulu, Pawlik, Kevin M., Fast, Vladimir G., Zumaquero, Esther, Lund, Frances E., Randall, Troy D., Townes, Tim M., Zhang, Jianyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405542/ https://www.ncbi.nlm.nih.gov/pubmed/30488760 http://dx.doi.org/10.1161/JAHA.118.010239

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