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Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta‐Analysis of 7 646 267 Participants From 135 Studies
BACKGROUND: Low birth weight has been associated with increased risk of type 2 diabetes mellitus, cardiovascular disease, and hypertension, but the risk at high birth weight levels remains uncertain. This systematic review and meta‐analysis aimed to clarify the shape of associations between birth we...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405546/ https://www.ncbi.nlm.nih.gov/pubmed/30486715 http://dx.doi.org/10.1161/JAHA.118.008870 |
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author | Knop, Marianne Ravn Geng, Ting‐Ting Gorny, Alexander Wilhelm Ding, Renyu Li, Changwei Ley, Sylvia H. Huang, Tao |
author_facet | Knop, Marianne Ravn Geng, Ting‐Ting Gorny, Alexander Wilhelm Ding, Renyu Li, Changwei Ley, Sylvia H. Huang, Tao |
author_sort | Knop, Marianne Ravn |
collection | PubMed |
description | BACKGROUND: Low birth weight has been associated with increased risk of type 2 diabetes mellitus, cardiovascular disease, and hypertension, but the risk at high birth weight levels remains uncertain. This systematic review and meta‐analysis aimed to clarify the shape of associations between birth weight and aforementioned diseases in adults and assessed sex‐specific risks. METHODS AND RESULTS: We systematically searched PubMed, EMBASE, and Web of Science for studies published between 1980 and October 2016. Studies of birth weight and type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and hypertension were included. Random‐effects models were used to derive the summary relative risks and corresponding 95% confidence intervals.We identified 49 studies with 4 053 367 participants assessing the association between birth weight and T2DM, 33 studies with 5 949 477 participants for CVD, and 53 studies with 4 335 149 participants for hypertension and high blood pressure. Sex‐specific binary analyses showed that only females had an increased risk of T2DM and CVD at the upper tail of the birth weight distribution. While categorical analyses of 6 birth weight groups and dose‐response analyses showed J‐shaped associations of birth weight with T2DM and CVD, the association was inverse with hypertension. The lowest risks for T2DM, CVD, and hypertension were observed at 3.5 to 4.0, 4.0 to 4.5, and 4.0 to 4.5 kg, respectively. CONCLUSIONS: These findings indicate that birth weight is associated with risk of T2DM and CVD in a J‐shaped manner and that this is more pronounced among females. |
format | Online Article Text |
id | pubmed-6405546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64055462019-03-21 Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta‐Analysis of 7 646 267 Participants From 135 Studies Knop, Marianne Ravn Geng, Ting‐Ting Gorny, Alexander Wilhelm Ding, Renyu Li, Changwei Ley, Sylvia H. Huang, Tao J Am Heart Assoc Systematic Review and Meta‐analysis BACKGROUND: Low birth weight has been associated with increased risk of type 2 diabetes mellitus, cardiovascular disease, and hypertension, but the risk at high birth weight levels remains uncertain. This systematic review and meta‐analysis aimed to clarify the shape of associations between birth weight and aforementioned diseases in adults and assessed sex‐specific risks. METHODS AND RESULTS: We systematically searched PubMed, EMBASE, and Web of Science for studies published between 1980 and October 2016. Studies of birth weight and type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and hypertension were included. Random‐effects models were used to derive the summary relative risks and corresponding 95% confidence intervals.We identified 49 studies with 4 053 367 participants assessing the association between birth weight and T2DM, 33 studies with 5 949 477 participants for CVD, and 53 studies with 4 335 149 participants for hypertension and high blood pressure. Sex‐specific binary analyses showed that only females had an increased risk of T2DM and CVD at the upper tail of the birth weight distribution. While categorical analyses of 6 birth weight groups and dose‐response analyses showed J‐shaped associations of birth weight with T2DM and CVD, the association was inverse with hypertension. The lowest risks for T2DM, CVD, and hypertension were observed at 3.5 to 4.0, 4.0 to 4.5, and 4.0 to 4.5 kg, respectively. CONCLUSIONS: These findings indicate that birth weight is associated with risk of T2DM and CVD in a J‐shaped manner and that this is more pronounced among females. John Wiley and Sons Inc. 2018-11-29 /pmc/articles/PMC6405546/ /pubmed/30486715 http://dx.doi.org/10.1161/JAHA.118.008870 Text en © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Systematic Review and Meta‐analysis Knop, Marianne Ravn Geng, Ting‐Ting Gorny, Alexander Wilhelm Ding, Renyu Li, Changwei Ley, Sylvia H. Huang, Tao Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta‐Analysis of 7 646 267 Participants From 135 Studies |
title | Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta‐Analysis of 7 646 267 Participants From 135 Studies |
title_full | Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta‐Analysis of 7 646 267 Participants From 135 Studies |
title_fullStr | Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta‐Analysis of 7 646 267 Participants From 135 Studies |
title_full_unstemmed | Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta‐Analysis of 7 646 267 Participants From 135 Studies |
title_short | Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta‐Analysis of 7 646 267 Participants From 135 Studies |
title_sort | birth weight and risk of type 2 diabetes mellitus, cardiovascular disease, and hypertension in adults: a meta‐analysis of 7 646 267 participants from 135 studies |
topic | Systematic Review and Meta‐analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405546/ https://www.ncbi.nlm.nih.gov/pubmed/30486715 http://dx.doi.org/10.1161/JAHA.118.008870 |
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