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Familial Mortality Risks in Patients With Heart Failure—A Swedish Sibling Study

BACKGROUND: The influence of familial factors on the prognosis of heart failure (HF) is unknown. This nationwide follow‐up study aimed to determine familial mortality risks of HF among Swedish siblings hospitalized for HF. METHODS AND RESULTS: We linked several Swedish nationwide registers for indiv...

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Autores principales: Lindgren, Magnus P., Smith, J. Gustav, Li, Xinjun, Sundquist, Jan, Sundquist, Kristina, Zöller, Bengt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405608/
https://www.ncbi.nlm.nih.gov/pubmed/30561269
http://dx.doi.org/10.1161/JAHA.118.010181
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author Lindgren, Magnus P.
Smith, J. Gustav
Li, Xinjun
Sundquist, Jan
Sundquist, Kristina
Zöller, Bengt
author_facet Lindgren, Magnus P.
Smith, J. Gustav
Li, Xinjun
Sundquist, Jan
Sundquist, Kristina
Zöller, Bengt
author_sort Lindgren, Magnus P.
collection PubMed
description BACKGROUND: The influence of familial factors on the prognosis of heart failure (HF) is unknown. This nationwide follow‐up study aimed to determine familial mortality risks of HF among Swedish siblings hospitalized for HF. METHODS AND RESULTS: We linked several Swedish nationwide registers for individuals aged 0 to 80 years. The study population consisted of 373 people hospitalized for HF for the first time between 2000 and 2012 with 1 proband sibling previously hospitalized for HF for the first time between 2000 and 2007. Families with congenital heart disease were excluded. Familial hazard ratios (HRs) for mortality after first HF hospitalization were determined with Cox regression. The influence of proband survival was categorized as short survival (<5 years) or long survival (≥5 years) and determined continuously for the initial 5 years of proband survival. Adjustments were made for age, sex, time period, and common HF comorbidities. Short proband survival was associated with a HR of 2.02 (95% confidence interval, 1.32–3.09) for overall mortality. This HR was 2.35 (95% confidence interval, 1.18–4.67) in patients without preceding coronary heart disease, whereas patients with ischemic HF had an HR of 1.84 (95% confidence interval, 1.05–3.23). For each year of proband survival, the risk of death decreased, with a HR of 0.86 (95% confidence interval, 0.77–0.98). CONCLUSIONS: Our results suggest that family history of poor survival in specific relation to HF is an important risk factor for death in HF patients. Additional studies are needed to characterize the molecular underpinnings and detailed phenotypic characteristics of such patients.
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spelling pubmed-64056082019-03-19 Familial Mortality Risks in Patients With Heart Failure—A Swedish Sibling Study Lindgren, Magnus P. Smith, J. Gustav Li, Xinjun Sundquist, Jan Sundquist, Kristina Zöller, Bengt J Am Heart Assoc Original Research BACKGROUND: The influence of familial factors on the prognosis of heart failure (HF) is unknown. This nationwide follow‐up study aimed to determine familial mortality risks of HF among Swedish siblings hospitalized for HF. METHODS AND RESULTS: We linked several Swedish nationwide registers for individuals aged 0 to 80 years. The study population consisted of 373 people hospitalized for HF for the first time between 2000 and 2012 with 1 proband sibling previously hospitalized for HF for the first time between 2000 and 2007. Families with congenital heart disease were excluded. Familial hazard ratios (HRs) for mortality after first HF hospitalization were determined with Cox regression. The influence of proband survival was categorized as short survival (<5 years) or long survival (≥5 years) and determined continuously for the initial 5 years of proband survival. Adjustments were made for age, sex, time period, and common HF comorbidities. Short proband survival was associated with a HR of 2.02 (95% confidence interval, 1.32–3.09) for overall mortality. This HR was 2.35 (95% confidence interval, 1.18–4.67) in patients without preceding coronary heart disease, whereas patients with ischemic HF had an HR of 1.84 (95% confidence interval, 1.05–3.23). For each year of proband survival, the risk of death decreased, with a HR of 0.86 (95% confidence interval, 0.77–0.98). CONCLUSIONS: Our results suggest that family history of poor survival in specific relation to HF is an important risk factor for death in HF patients. Additional studies are needed to characterize the molecular underpinnings and detailed phenotypic characteristics of such patients. John Wiley and Sons Inc. 2018-12-14 /pmc/articles/PMC6405608/ /pubmed/30561269 http://dx.doi.org/10.1161/JAHA.118.010181 Text en © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Lindgren, Magnus P.
Smith, J. Gustav
Li, Xinjun
Sundquist, Jan
Sundquist, Kristina
Zöller, Bengt
Familial Mortality Risks in Patients With Heart Failure—A Swedish Sibling Study
title Familial Mortality Risks in Patients With Heart Failure—A Swedish Sibling Study
title_full Familial Mortality Risks in Patients With Heart Failure—A Swedish Sibling Study
title_fullStr Familial Mortality Risks in Patients With Heart Failure—A Swedish Sibling Study
title_full_unstemmed Familial Mortality Risks in Patients With Heart Failure—A Swedish Sibling Study
title_short Familial Mortality Risks in Patients With Heart Failure—A Swedish Sibling Study
title_sort familial mortality risks in patients with heart failure—a swedish sibling study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405608/
https://www.ncbi.nlm.nih.gov/pubmed/30561269
http://dx.doi.org/10.1161/JAHA.118.010181
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