Transcription Factor EB Activation Rescues Advanced αB‐Crystallin Mutation‐Induced Cardiomyopathy by Normalizing Desmin Localization

BACKGROUND: Mutations in αB‐crystallin result in proteotoxic cardiomyopathy with desmin mislocalization to protein aggregates. Intermittent fasting (IF) is a novel approach to activate transcription factor EB (TFEB), a master regulator of the autophagy‐lysosomal pathway, in the myocardium. We tested...

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Detalles Bibliográficos
Autores principales: Ma, Xiucui, Mani, Kartik, Liu, Haiyan, Kovacs, Attila, Murphy, John T., Foroughi, Layla, French, Brent A., Weinheimer, Carla J., Kraja, Aldi, Benjamin, Ivor J., Hill, Joseph A., Javaheri, Ali, Diwan, Abhinav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405666/
https://www.ncbi.nlm.nih.gov/pubmed/30773991
http://dx.doi.org/10.1161/JAHA.118.010866

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