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Associations of Accelerometer‐Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study

BACKGROUND: Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light‐intensity physical activity or moderate‐to‐vigorous intensity physical activity; however, existing studies are limited by cross‐sectional study designs. METHODS AND RESULTS: Participant...

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Autores principales: Whitaker, Kara M., Pettee Gabriel, Kelley, Buman, Matthew P., Pereira, Mark A., Jacobs, David R., Reis, Jared P., Gibbs, Bethany Barone, Carnethon, Mercedes R., Staudenmayer, John, Sidney, Stephen, Sternfeld, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405708/
https://www.ncbi.nlm.nih.gov/pubmed/30616480
http://dx.doi.org/10.1161/JAHA.118.010212
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author Whitaker, Kara M.
Pettee Gabriel, Kelley
Buman, Matthew P.
Pereira, Mark A.
Jacobs, David R.
Reis, Jared P.
Gibbs, Bethany Barone
Carnethon, Mercedes R.
Staudenmayer, John
Sidney, Stephen
Sternfeld, Barbara
author_facet Whitaker, Kara M.
Pettee Gabriel, Kelley
Buman, Matthew P.
Pereira, Mark A.
Jacobs, David R.
Reis, Jared P.
Gibbs, Bethany Barone
Carnethon, Mercedes R.
Staudenmayer, John
Sidney, Stephen
Sternfeld, Barbara
author_sort Whitaker, Kara M.
collection PubMed
description BACKGROUND: Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light‐intensity physical activity or moderate‐to‐vigorous intensity physical activity; however, existing studies are limited by cross‐sectional study designs. METHODS AND RESULTS: Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light‐intensity physical activity, and moderate‐to‐vigorous intensity physical activity at year 20 (2005–2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high‐density lipoprotein cholesterol, and a composite risk score at year 30 (2015–2016). Models then examined change in activity with change in cardiometabolic risk over the same 10‐year period. Replacing 30 min/day of sedentary time with 30 min/day of light‐intensity physical activity at year 20 was associated with a lower composite risk score (−0.01 SD [95% CI, −0.02, −0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95% CI, −0.27, 0.02]), insulin (0.20 μU/mL [95% CI, −0.35, −0.04]), and higher high‐density lipoprotein cholesterol (0.20 mg/dL [95% CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score (−0.08 [95% CI, −0.13, −0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95% CI, −2.21, −0.84]), insulin (−1.13 μU/mL [95% CI, −1.95, −0.31]), triglycerides (−6.92 mg/dL [95% CI, −11.69, −2.15]), and an increase in high‐density lipoprotein cholesterol (1.59 mg/dL [95% CI, 0.45, 2.73]; all P<0.05). CONCLUSIONS: Replacement of sedentary time with light‐intensity physical activity or moderate‐to‐vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later.
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spelling pubmed-64057082019-03-21 Associations of Accelerometer‐Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study Whitaker, Kara M. Pettee Gabriel, Kelley Buman, Matthew P. Pereira, Mark A. Jacobs, David R. Reis, Jared P. Gibbs, Bethany Barone Carnethon, Mercedes R. Staudenmayer, John Sidney, Stephen Sternfeld, Barbara J Am Heart Assoc Original Research BACKGROUND: Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light‐intensity physical activity or moderate‐to‐vigorous intensity physical activity; however, existing studies are limited by cross‐sectional study designs. METHODS AND RESULTS: Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light‐intensity physical activity, and moderate‐to‐vigorous intensity physical activity at year 20 (2005–2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high‐density lipoprotein cholesterol, and a composite risk score at year 30 (2015–2016). Models then examined change in activity with change in cardiometabolic risk over the same 10‐year period. Replacing 30 min/day of sedentary time with 30 min/day of light‐intensity physical activity at year 20 was associated with a lower composite risk score (−0.01 SD [95% CI, −0.02, −0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95% CI, −0.27, 0.02]), insulin (0.20 μU/mL [95% CI, −0.35, −0.04]), and higher high‐density lipoprotein cholesterol (0.20 mg/dL [95% CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score (−0.08 [95% CI, −0.13, −0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95% CI, −2.21, −0.84]), insulin (−1.13 μU/mL [95% CI, −1.95, −0.31]), triglycerides (−6.92 mg/dL [95% CI, −11.69, −2.15]), and an increase in high‐density lipoprotein cholesterol (1.59 mg/dL [95% CI, 0.45, 2.73]; all P<0.05). CONCLUSIONS: Replacement of sedentary time with light‐intensity physical activity or moderate‐to‐vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later. John Wiley and Sons Inc. 2019-01-08 /pmc/articles/PMC6405708/ /pubmed/30616480 http://dx.doi.org/10.1161/JAHA.118.010212 Text en © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Whitaker, Kara M.
Pettee Gabriel, Kelley
Buman, Matthew P.
Pereira, Mark A.
Jacobs, David R.
Reis, Jared P.
Gibbs, Bethany Barone
Carnethon, Mercedes R.
Staudenmayer, John
Sidney, Stephen
Sternfeld, Barbara
Associations of Accelerometer‐Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study
title Associations of Accelerometer‐Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study
title_full Associations of Accelerometer‐Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study
title_fullStr Associations of Accelerometer‐Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study
title_full_unstemmed Associations of Accelerometer‐Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study
title_short Associations of Accelerometer‐Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study
title_sort associations of accelerometer‐measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors: the cardia study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405708/
https://www.ncbi.nlm.nih.gov/pubmed/30616480
http://dx.doi.org/10.1161/JAHA.118.010212
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