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Adherence to Statin Therapy Among US Adults Between 2007 and 2014

BACKGROUND: Prior studies suggest that persistence with and adherence to statin therapy is low. Interventions to improve statin persistence and adherence have been developed over the past decade. METHODS AND RESULTS: This was a retrospective cohort study of adults aged ≥21 y with commercial or gover...

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Autores principales: Colantonio, Lisandro D., Rosenson, Robert S., Deng, Luqin, Monda, Keri L., Dai, Yuling, Farkouh, Michael E., Safford, Monika M., Philip, Kiran, Mues, Katherine E., Muntner, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405715/
https://www.ncbi.nlm.nih.gov/pubmed/30616455
http://dx.doi.org/10.1161/JAHA.118.010376
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author Colantonio, Lisandro D.
Rosenson, Robert S.
Deng, Luqin
Monda, Keri L.
Dai, Yuling
Farkouh, Michael E.
Safford, Monika M.
Philip, Kiran
Mues, Katherine E.
Muntner, Paul
author_facet Colantonio, Lisandro D.
Rosenson, Robert S.
Deng, Luqin
Monda, Keri L.
Dai, Yuling
Farkouh, Michael E.
Safford, Monika M.
Philip, Kiran
Mues, Katherine E.
Muntner, Paul
author_sort Colantonio, Lisandro D.
collection PubMed
description BACKGROUND: Prior studies suggest that persistence with and adherence to statin therapy is low. Interventions to improve statin persistence and adherence have been developed over the past decade. METHODS AND RESULTS: This was a retrospective cohort study of adults aged ≥21 y with commercial or government health insurance in the MarketScan (Truven Health Analytics) and Medicare databases who initiated statins in 2007–2014 and (1) started treatment after a myocardial infarction (n=201 573), (2) had diabetes mellitus but without coronary heart disease (CHD; n=610 049), or (3) did not have CHD or diabetes mellitus (n=2 244 868). Persistence with (ie, not discontinuing treatment) and high adherence to statin therapy were assessed using pharmacy fills in the year following treatment initiation. In 2007 and 2014, the proportions of patients persistent with statin therapy were 78.1% and 79.1%, respectively, among those initiating treatment following myocardial infarction; 66.5% and 67.3%, respectively, for those with diabetes mellitus but without CHD; and 64.3% and 63.9%, respectively, for those without CHD or diabetes mellitus. Between 2007 and 2014, high adherence to statin therapy increased from 57.9% to 63.8% among patients initiating treatment following myocardial infarction and from 34.9% to 37.6% among those with diabetes mellitus but without CHD (each P (trend)<0.001). Among patients without CHD or diabetes mellitus, high adherence did not improve between 2007 (35.7%) and 2014 (36.8%; P (trend)=0.14). In 2014, statin adherence was lower among younger, black, and Hispanic patients versus white patients and those initiating a high‐intensity statin dosage. Statin adherence was higher among men and patients with cardiologist care following treatment initiation. CONCLUSIONS: Persistence with and adherence to statin therapy remain low, particularly among those without CHD.
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spelling pubmed-64057152019-03-21 Adherence to Statin Therapy Among US Adults Between 2007 and 2014 Colantonio, Lisandro D. Rosenson, Robert S. Deng, Luqin Monda, Keri L. Dai, Yuling Farkouh, Michael E. Safford, Monika M. Philip, Kiran Mues, Katherine E. Muntner, Paul J Am Heart Assoc Original Research BACKGROUND: Prior studies suggest that persistence with and adherence to statin therapy is low. Interventions to improve statin persistence and adherence have been developed over the past decade. METHODS AND RESULTS: This was a retrospective cohort study of adults aged ≥21 y with commercial or government health insurance in the MarketScan (Truven Health Analytics) and Medicare databases who initiated statins in 2007–2014 and (1) started treatment after a myocardial infarction (n=201 573), (2) had diabetes mellitus but without coronary heart disease (CHD; n=610 049), or (3) did not have CHD or diabetes mellitus (n=2 244 868). Persistence with (ie, not discontinuing treatment) and high adherence to statin therapy were assessed using pharmacy fills in the year following treatment initiation. In 2007 and 2014, the proportions of patients persistent with statin therapy were 78.1% and 79.1%, respectively, among those initiating treatment following myocardial infarction; 66.5% and 67.3%, respectively, for those with diabetes mellitus but without CHD; and 64.3% and 63.9%, respectively, for those without CHD or diabetes mellitus. Between 2007 and 2014, high adherence to statin therapy increased from 57.9% to 63.8% among patients initiating treatment following myocardial infarction and from 34.9% to 37.6% among those with diabetes mellitus but without CHD (each P (trend)<0.001). Among patients without CHD or diabetes mellitus, high adherence did not improve between 2007 (35.7%) and 2014 (36.8%; P (trend)=0.14). In 2014, statin adherence was lower among younger, black, and Hispanic patients versus white patients and those initiating a high‐intensity statin dosage. Statin adherence was higher among men and patients with cardiologist care following treatment initiation. CONCLUSIONS: Persistence with and adherence to statin therapy remain low, particularly among those without CHD. John Wiley and Sons Inc. 2019-01-08 /pmc/articles/PMC6405715/ /pubmed/30616455 http://dx.doi.org/10.1161/JAHA.118.010376 Text en © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Colantonio, Lisandro D.
Rosenson, Robert S.
Deng, Luqin
Monda, Keri L.
Dai, Yuling
Farkouh, Michael E.
Safford, Monika M.
Philip, Kiran
Mues, Katherine E.
Muntner, Paul
Adherence to Statin Therapy Among US Adults Between 2007 and 2014
title Adherence to Statin Therapy Among US Adults Between 2007 and 2014
title_full Adherence to Statin Therapy Among US Adults Between 2007 and 2014
title_fullStr Adherence to Statin Therapy Among US Adults Between 2007 and 2014
title_full_unstemmed Adherence to Statin Therapy Among US Adults Between 2007 and 2014
title_short Adherence to Statin Therapy Among US Adults Between 2007 and 2014
title_sort adherence to statin therapy among us adults between 2007 and 2014
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405715/
https://www.ncbi.nlm.nih.gov/pubmed/30616455
http://dx.doi.org/10.1161/JAHA.118.010376
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