Bcl-x(L) inhibition enhances Dinaciclib-induced cell death in soft-tissue sarcomas

Soft-tissue sarcomas (STS) are an uncommon and heterogeneous group of malignancies that result in high mortality. Metastatic STS have very bad prognosis due to the lack of effective treatments. Dinaciclib is a model drug for the family of CDK inhibitors. Its main targets are cell cycle regulator CDK...

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Detalles Bibliográficos
Autores principales: Rello-Varona, Santi, Fuentes-Guirado, Miriam, López-Alemany, Roser, Contreras-Pérez, Aida, Mulet-Margalef, Núria, García-Monclús, Silvia, Tirado, Oscar M., García del Muro, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405759/
https://www.ncbi.nlm.nih.gov/pubmed/30846724
http://dx.doi.org/10.1038/s41598-019-40106-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405759/
https://www.ncbi.nlm.nih.gov/pubmed/30846724
http://dx.doi.org/10.1038/s41598-019-40106-7

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