Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation

The mRNA processing and export factor, Iws1, interacts with the histone H3/H4 chaperone, Spt6 (Supt6 in mouse gene ontology) and recruits the lysine methyltransferase, Setd2, to chromatin to regulate H3K36me3. This recruitment is known to be crucial for pre-mRNA splicing and Iws1 has been shown to i...

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Detalles Bibliográficos
Autores principales: Oqani, Reza K., Lin, Tao, Lee, Jae Eun, Kang, Jeong Won, Shin, Hyun Young, Il Jin, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405902/
https://www.ncbi.nlm.nih.gov/pubmed/30846735
http://dx.doi.org/10.1038/s41598-019-40358-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405902/
https://www.ncbi.nlm.nih.gov/pubmed/30846735
http://dx.doi.org/10.1038/s41598-019-40358-3

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