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Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity

Obesity, and associated metabolic syndrome, have been identified as primary risk factors for the development of knee osteoarthritis (OA), representing nearly 60% of the OA patient population. In this study, we sought to determine the effects of prebiotic fibre supplementation, aerobic exercise, and...

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Autores principales: Rios, Jaqueline Lourdes, Bomhof, Marc R., Reimer, Raylene A., Hart, David A., Collins, Kelsey H., Herzog, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405910/
https://www.ncbi.nlm.nih.gov/pubmed/30846801
http://dx.doi.org/10.1038/s41598-019-40601-x
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author Rios, Jaqueline Lourdes
Bomhof, Marc R.
Reimer, Raylene A.
Hart, David A.
Collins, Kelsey H.
Herzog, Walter
author_facet Rios, Jaqueline Lourdes
Bomhof, Marc R.
Reimer, Raylene A.
Hart, David A.
Collins, Kelsey H.
Herzog, Walter
author_sort Rios, Jaqueline Lourdes
collection PubMed
description Obesity, and associated metabolic syndrome, have been identified as primary risk factors for the development of knee osteoarthritis (OA), representing nearly 60% of the OA patient population. In this study, we sought to determine the effects of prebiotic fibre supplementation, aerobic exercise, and the combination of the two interventions, on the development of metabolic knee osteoarthritis in a high-fat/high-sucrose (HFS) diet-induced rat model of obesity. Twelve-week-old male Sprague-Dawley rats were randomized into five groups: a non-exercising control group fed a standard chow diet, a non-exercising group fed a HFS diet, a non-exercising group fed a HFS diet combined with prebiotic fibre supplement, an exercise group fed a HFS diet, and an exercise group fed a HFS diet combined with prebiotic fibre supplement. Outcome measures included knee joint damage, percent body fat, insulin sensitivity, serum lipid profile, serum endotoxin, serum and synovial fluid cytokines and adipokines, and cecal microbiota. Prebiotic fibre supplementation, aerobic exercise, and the combination of the two interventions completely prevented knee joint damage that is otherwise observed in this rat model of obesity. Prevention of knee damage was associated with a normalization of insulin resistance, leptin levels, dyslipidemia, gut microbiota, and endotoxemia in the HFS-fed rats.
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spelling pubmed-64059102019-03-12 Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity Rios, Jaqueline Lourdes Bomhof, Marc R. Reimer, Raylene A. Hart, David A. Collins, Kelsey H. Herzog, Walter Sci Rep Article Obesity, and associated metabolic syndrome, have been identified as primary risk factors for the development of knee osteoarthritis (OA), representing nearly 60% of the OA patient population. In this study, we sought to determine the effects of prebiotic fibre supplementation, aerobic exercise, and the combination of the two interventions, on the development of metabolic knee osteoarthritis in a high-fat/high-sucrose (HFS) diet-induced rat model of obesity. Twelve-week-old male Sprague-Dawley rats were randomized into five groups: a non-exercising control group fed a standard chow diet, a non-exercising group fed a HFS diet, a non-exercising group fed a HFS diet combined with prebiotic fibre supplement, an exercise group fed a HFS diet, and an exercise group fed a HFS diet combined with prebiotic fibre supplement. Outcome measures included knee joint damage, percent body fat, insulin sensitivity, serum lipid profile, serum endotoxin, serum and synovial fluid cytokines and adipokines, and cecal microbiota. Prebiotic fibre supplementation, aerobic exercise, and the combination of the two interventions completely prevented knee joint damage that is otherwise observed in this rat model of obesity. Prevention of knee damage was associated with a normalization of insulin resistance, leptin levels, dyslipidemia, gut microbiota, and endotoxemia in the HFS-fed rats. Nature Publishing Group UK 2019-03-07 /pmc/articles/PMC6405910/ /pubmed/30846801 http://dx.doi.org/10.1038/s41598-019-40601-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Rios, Jaqueline Lourdes
Bomhof, Marc R.
Reimer, Raylene A.
Hart, David A.
Collins, Kelsey H.
Herzog, Walter
Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity
title Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity
title_full Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity
title_fullStr Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity
title_full_unstemmed Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity
title_short Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity
title_sort protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405910/
https://www.ncbi.nlm.nih.gov/pubmed/30846801
http://dx.doi.org/10.1038/s41598-019-40601-x
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