Direct Analysis of Incorporation of an Anticancer Drug into DNA at Single-Molecule Resolution

Identifying positions at which anticancer drug molecules incorporate into DNA is essential to define mechanisms underlying their activity, but current methodologies cannot yet achieve this. The thymidine fluorine substitution product trifluridine (FTD) is a DNA-damaging anticancer agent thought to i...

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Detalles Bibliográficos
Autores principales: Ohshiro, Takahito, Komoto, Yuuki, Konno, Masamitsu, Koseki, Jun, Asai, Ayumu, Ishii, Hideshi, Taniguchi, Masateru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405915/
https://www.ncbi.nlm.nih.gov/pubmed/30846775
http://dx.doi.org/10.1038/s41598-019-40504-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405915/
https://www.ncbi.nlm.nih.gov/pubmed/30846775
http://dx.doi.org/10.1038/s41598-019-40504-x

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