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Direct Analysis of Incorporation of an Anticancer Drug into DNA at Single-Molecule Resolution
Identifying positions at which anticancer drug molecules incorporate into DNA is essential to define mechanisms underlying their activity, but current methodologies cannot yet achieve this. The thymidine fluorine substitution product trifluridine (FTD) is a DNA-damaging anticancer agent thought to i...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405915/ https://www.ncbi.nlm.nih.gov/pubmed/30846775 http://dx.doi.org/10.1038/s41598-019-40504-x |