2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype

Due to limited availability of pharmacological therapies, triple-negative breast cancer (TNBC) is the subtype with worst outcome. We hypothesised that 2-Deoxy-D-Glucose (2-DG), a glucose analogue, may hold potential as a therapy for particularly aggressive TNBC. We investigated 2-DG’s effects on TNB...

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Detalles Bibliográficos
Autores principales: O’Neill, Sadhbh, Porter, Richard K., McNamee, Niamh, Martinez, Vanesa G., O’Driscoll, Lorraine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405919/
https://www.ncbi.nlm.nih.gov/pubmed/30846710
http://dx.doi.org/10.1038/s41598-019-39789-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405919/
https://www.ncbi.nlm.nih.gov/pubmed/30846710
http://dx.doi.org/10.1038/s41598-019-39789-9

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