Cargando…

2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype

Due to limited availability of pharmacological therapies, triple-negative breast cancer (TNBC) is the subtype with worst outcome. We hypothesised that 2-Deoxy-D-Glucose (2-DG), a glucose analogue, may hold potential as a therapy for particularly aggressive TNBC. We investigated 2-DG’s effects on TNB...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Neill, Sadhbh, Porter, Richard K., McNamee, Niamh, Martinez, Vanesa G., O’Driscoll, Lorraine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405919/ https://www.ncbi.nlm.nih.gov/pubmed/30846710 http://dx.doi.org/10.1038/s41598-019-39789-9

Ejemplares similares

An extensive study of potential inhibitors of extracellular vesicles release in triple-negative breast cancer
por: McNamee, Niamh, et al.
Publicado: (2023)

Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles
por: Martinez, Vanesa G., et al.
Publicado: (2017)

Doxorubicin Loading into Milk and Mesenchymal Stem Cells’ Extracellular Vesicles as Drug Delivery Vehicles
por: Mukhopadhya, Anindya, et al.
Publicado: (2023)

A method of separating extracellular vesicles from blood shows potential clinical translation, and reveals extracellular vesicle cargo gremlin-1 as a diagnostic biomarker
por: McNamee, Niamh, et al.
Publicado: (2021)

Proteomics profiling identifies extracellular vesicles’ cargo associated with tumour cell induced platelet aggregation
por: McNamee, Niamh, et al.
Publicado: (2022)

miR-758-3p: a blood-based biomarker that’s influence on the expression of CERP/ABCA1 may contribute to the progression of obesity to metabolic syndrome
por: O’Neill, Sadhbh, et al.
Publicado: (2018)

miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity
por: O'Brien, Keith, et al.
Publicado: (2015)

The relevance of using 3D cell cultures, in addition to 2D monolayer cultures, when evaluating breast cancer drug sensitivity and resistance
por: Breslin, Susan, et al.
Publicado: (2016)

Extracellular vesicles from mesenchymal stem cells as a Covid-19 treatment
por: O’Driscoll, Lorraine
Publicado: (2020)

Non-thermal plasma with 2-deoxy-D-glucose synergistically induces cell death by targeting glycolysis in blood cancer cells
por: Kaushik, Neha, et al.
Publicado: (2015)

Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications
por: Tsiapalis, Dimitrios, et al.
Publicado: (2020)

Pre-Clinical In Vitro Models Used in Cancer Research: Results of a Worldwide Survey
por: Martinez-Pacheco, Sarai, et al.
Publicado: (2021)

The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair
por: Fallahi, Emma, et al.
Publicado: (2016)

Comparison of three commercial serological tests for the detection of Chlamydia abortus infection in ewes
por: O’Neill, L. M., et al.
Publicado: (2018)

Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
por: O'Neill, Amanda J, et al.
Publicado: (2011)

Triple Negative Breast Cancer is Dependent on the Lysosomal Cholesterol Transporter NPC1
por: O’Neill, Kathleen
Publicado: (2021)

Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes
por: Corcoran, Claire, et al.
Publicado: (2012)

SAT-145 Cholesterol Uptake as a Critical Vulnerability in Triple Negative Breast Cancer
por: O’Neill, Kathleen
Publicado: (2020)

Extracellular vesicles report on the MET status of their cells of origin regardless of the method used for their isolation
por: Useckaite, Zivile, et al.
Publicado: (2020)

Advanced Maternal Age and Adverse Pregnancy Outcome: Evidence from a Large Contemporary Cohort
por: Kenny, Louise C., et al.
Publicado: (2013)

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors
por: Catalano, Mariadelva, et al.
Publicado: (2019)

Small-Cell Lung Cancer—An Update on Targeted and Immunotherapies
por: McNamee, Nicholas, et al.
Publicado: (2023)

miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer
por: Corcoran, Claire, et al.
Publicado: (2014)

Evidence for the Need to Evaluate More Than One Source of Extracellular Vesicles, Rather Than Single or Pooled Samples Only, When Comparing Extracellular Vesicles Separation Methods
por: Martinez-Pacheco, Sarai, et al.
Publicado: (2021)

Extracellular vesicle separation from milk and infant milk formula using acid precipitation and ultracentrifugation
por: Mukhopadhya, Anindya, et al.
Publicado: (2021)

Modeling timelines for translational science in cancer; the impact of technological maturation
por: McNamee, Laura M., et al.
Publicado: (2017)

Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis
por: Wang, Jichuang, et al.
Publicado: (2014)

Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation
por: Gill, Catherine, et al.
Publicado: (2009)

Neratinib resistance and cross-resistance to other HER2-targeted drugs due to increased activity of metabolism enzyme cytochrome P4503A4
por: Breslin, Susan, et al.
Publicado: (2017)

Dual Effect of Combined Metformin and 2-Deoxy-D-Glucose Treatment on Mitochondrial Biogenesis and PD-L1 Expression in Triple-Negative Breast Cancer Cells
por: Repas, Jernej, et al.
Publicado: (2022)

RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer
por: Prokakis, Evangelos, et al.
Publicado: (2023)

Exercise Training and Circulating Small Extracellular Vesicles: Appraisal of Methodological Approaches and Current Knowledge
por: Darragh, Ian A. J., et al.
Publicado: (2021)

The effect of ‘paying for performance’ on the management of type 2 diabetes mellitus: a cross-sectional observational study
por: O'Connor, Raymond, et al.
Publicado: (2020)

Hexokinase 2 Is a Pivot for Lovastatin-induced Glycolysis-to-Autophagy Reprogramming in Triple-Negative Breast Cancer Cells
por: Xue, Lian, et al.
Publicado: (2022)

Enhanced Radiosensitivity and Chemosensitivity of Breast Cancer Cells by 2-Deoxy-D-Glucose in Combination Therapy
por: Aghaee, Fahimeh, et al.
Publicado: (2012)

PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose
por: Tee, Sui Seng, et al.
Publicado: (2017)

Isosteviol Has Beneficial Effects on Palmitate-Induced α-Cell Dysfunction and Gene Expression
por: Chen, Xiaoping, et al.
Publicado: (2012)

Vimentin Promotes the Aggressiveness of Triple Negative Breast Cancer Cells Surviving Chemotherapeutic Treatment
por: Winter, Marie, et al.
Publicado: (2021)

Interacting with patients at risk of self-harm or suicide - A qualitative study of community pharmacists and pharmacy staff
por: O'Driscoll, Michelle, et al.
Publicado: (2023)

Hairless Expression Attenuates Apoptosis in a Mouse Model and the COS Cell Line; Involvement of p53
por: O'Driscoll, Cliona, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_josn38788j8b6sa4g9imad095q