Development of a bioassay to detect T-cell-activating impurities for T-cell-dependent bispecific antibodies

T-cell-dependent bispecific antibodies (TDBs) are promising cancer immunotherapies that recruit a patient’s T cells to kill cancer cells. There are increasing numbers of TBDs in clinical trials, demonstrating their widely recognized therapeutic potential. Due to the fact that TDBs engage and activat...

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Detalles Bibliográficos
Autores principales: Lee, Ho Young, Contreras, Edward, Register, Ames C., Wu, Qiang, Abadie, Kathleen, Garcia, Khristofer, Wong, Pin Yee, Jiang, Guoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405939/
https://www.ncbi.nlm.nih.gov/pubmed/30846832
http://dx.doi.org/10.1038/s41598-019-40689-1

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