Cargando…
Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia
Candida albicans is the most frequently isolated fungal species in hospital settings worldwide. However, non-albicans Candida species with decreased susceptibility to antifungals have emerged as an important cause of fungemia. The aims of this study were to determine the species distribution of fung...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405987/ https://www.ncbi.nlm.nih.gov/pubmed/30846717 http://dx.doi.org/10.1038/s41598-019-40280-8 |
_version_ | 1783401197161414656 |
---|---|
author | Lindberg, Erika Hammarström, Helena Ataollahy, Nasser Kondori, Nahid |
author_facet | Lindberg, Erika Hammarström, Helena Ataollahy, Nasser Kondori, Nahid |
author_sort | Lindberg, Erika |
collection | PubMed |
description | Candida albicans is the most frequently isolated fungal species in hospital settings worldwide. However, non-albicans Candida species with decreased susceptibility to antifungals have emerged as an important cause of fungemia. The aims of this study were to determine the species distribution of fungi isolated from the blood samples of patients at a Swedish University Hospital and to define the in vitro susceptibilities of these isolates to nine antifungal agents. In total, 233 yeast isolates from 143 patients were included in this study. Antifungal susceptibility testing was performed using broth dilution Sensititre YeastOne panels, which comprised amphotericin B, 5-flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, micafungin, and caspofungin. The most common species in all age groups was C. albicans (n = 93, 65%), followed by C. glabrata (n = 27, 19%) and C. parapsilosis (n = 15, 10%). C. glabrata was mostly found in elderly individuals, while C. parapsilosis was found mainly in young children (p = 0.008). Antifungal resistance was low in the Candida species, except for reduced susceptibility to fluconazole among C. glabrata strains. C. albicans is the most frequent colonizer of Swedish patients. In general antifungal resistance is uncommon in Candida species. Nevertheless, reduced susceptibilities to fluconazole and echinocandins were found in C. glabrata and C. parapsilosis, respectively. |
format | Online Article Text |
id | pubmed-6405987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64059872019-03-12 Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia Lindberg, Erika Hammarström, Helena Ataollahy, Nasser Kondori, Nahid Sci Rep Article Candida albicans is the most frequently isolated fungal species in hospital settings worldwide. However, non-albicans Candida species with decreased susceptibility to antifungals have emerged as an important cause of fungemia. The aims of this study were to determine the species distribution of fungi isolated from the blood samples of patients at a Swedish University Hospital and to define the in vitro susceptibilities of these isolates to nine antifungal agents. In total, 233 yeast isolates from 143 patients were included in this study. Antifungal susceptibility testing was performed using broth dilution Sensititre YeastOne panels, which comprised amphotericin B, 5-flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, micafungin, and caspofungin. The most common species in all age groups was C. albicans (n = 93, 65%), followed by C. glabrata (n = 27, 19%) and C. parapsilosis (n = 15, 10%). C. glabrata was mostly found in elderly individuals, while C. parapsilosis was found mainly in young children (p = 0.008). Antifungal resistance was low in the Candida species, except for reduced susceptibility to fluconazole among C. glabrata strains. C. albicans is the most frequent colonizer of Swedish patients. In general antifungal resistance is uncommon in Candida species. Nevertheless, reduced susceptibilities to fluconazole and echinocandins were found in C. glabrata and C. parapsilosis, respectively. Nature Publishing Group UK 2019-03-07 /pmc/articles/PMC6405987/ /pubmed/30846717 http://dx.doi.org/10.1038/s41598-019-40280-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Lindberg, Erika Hammarström, Helena Ataollahy, Nasser Kondori, Nahid Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia |
title | Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia |
title_full | Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia |
title_fullStr | Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia |
title_full_unstemmed | Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia |
title_short | Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia |
title_sort | species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405987/ https://www.ncbi.nlm.nih.gov/pubmed/30846717 http://dx.doi.org/10.1038/s41598-019-40280-8 |
work_keys_str_mv | AT lindbergerika speciesdistributionandantifungaldrugsusceptibilitiesofyeastsisolatedfromthebloodsamplesofpatientswithcandidemia AT hammarstromhelena speciesdistributionandantifungaldrugsusceptibilitiesofyeastsisolatedfromthebloodsamplesofpatientswithcandidemia AT ataollahynasser speciesdistributionandantifungaldrugsusceptibilitiesofyeastsisolatedfromthebloodsamplesofpatientswithcandidemia AT kondorinahid speciesdistributionandantifungaldrugsusceptibilitiesofyeastsisolatedfromthebloodsamplesofpatientswithcandidemia |