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Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia

Candida albicans is the most frequently isolated fungal species in hospital settings worldwide. However, non-albicans Candida species with decreased susceptibility to antifungals have emerged as an important cause of fungemia. The aims of this study were to determine the species distribution of fung...

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Autores principales: Lindberg, Erika, Hammarström, Helena, Ataollahy, Nasser, Kondori, Nahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405987/
https://www.ncbi.nlm.nih.gov/pubmed/30846717
http://dx.doi.org/10.1038/s41598-019-40280-8
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author Lindberg, Erika
Hammarström, Helena
Ataollahy, Nasser
Kondori, Nahid
author_facet Lindberg, Erika
Hammarström, Helena
Ataollahy, Nasser
Kondori, Nahid
author_sort Lindberg, Erika
collection PubMed
description Candida albicans is the most frequently isolated fungal species in hospital settings worldwide. However, non-albicans Candida species with decreased susceptibility to antifungals have emerged as an important cause of fungemia. The aims of this study were to determine the species distribution of fungi isolated from the blood samples of patients at a Swedish University Hospital and to define the in vitro susceptibilities of these isolates to nine antifungal agents. In total, 233 yeast isolates from 143 patients were included in this study. Antifungal susceptibility testing was performed using broth dilution Sensititre YeastOne panels, which comprised amphotericin B, 5-flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, micafungin, and caspofungin. The most common species in all age groups was C. albicans (n = 93, 65%), followed by C. glabrata (n = 27, 19%) and C. parapsilosis (n = 15, 10%). C. glabrata was mostly found in elderly individuals, while C. parapsilosis was found mainly in young children (p = 0.008). Antifungal resistance was low in the Candida species, except for reduced susceptibility to fluconazole among C. glabrata strains. C. albicans is the most frequent colonizer of Swedish patients. In general antifungal resistance is uncommon in Candida species. Nevertheless, reduced susceptibilities to fluconazole and echinocandins were found in C. glabrata and C. parapsilosis, respectively.
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spelling pubmed-64059872019-03-12 Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia Lindberg, Erika Hammarström, Helena Ataollahy, Nasser Kondori, Nahid Sci Rep Article Candida albicans is the most frequently isolated fungal species in hospital settings worldwide. However, non-albicans Candida species with decreased susceptibility to antifungals have emerged as an important cause of fungemia. The aims of this study were to determine the species distribution of fungi isolated from the blood samples of patients at a Swedish University Hospital and to define the in vitro susceptibilities of these isolates to nine antifungal agents. In total, 233 yeast isolates from 143 patients were included in this study. Antifungal susceptibility testing was performed using broth dilution Sensititre YeastOne panels, which comprised amphotericin B, 5-flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, micafungin, and caspofungin. The most common species in all age groups was C. albicans (n = 93, 65%), followed by C. glabrata (n = 27, 19%) and C. parapsilosis (n = 15, 10%). C. glabrata was mostly found in elderly individuals, while C. parapsilosis was found mainly in young children (p = 0.008). Antifungal resistance was low in the Candida species, except for reduced susceptibility to fluconazole among C. glabrata strains. C. albicans is the most frequent colonizer of Swedish patients. In general antifungal resistance is uncommon in Candida species. Nevertheless, reduced susceptibilities to fluconazole and echinocandins were found in C. glabrata and C. parapsilosis, respectively. Nature Publishing Group UK 2019-03-07 /pmc/articles/PMC6405987/ /pubmed/30846717 http://dx.doi.org/10.1038/s41598-019-40280-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Lindberg, Erika
Hammarström, Helena
Ataollahy, Nasser
Kondori, Nahid
Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia
title Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia
title_full Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia
title_fullStr Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia
title_full_unstemmed Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia
title_short Species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia
title_sort species distribution and antifungal drug susceptibilities of yeasts isolated from the blood samples of patients with candidemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405987/
https://www.ncbi.nlm.nih.gov/pubmed/30846717
http://dx.doi.org/10.1038/s41598-019-40280-8
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