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Sleep duration and psychotic experiences in patients at risk of psychosis: A secondary analysis of the EDIE-2 trial

Sleep disturbance is common among individuals at risk of psychosis, yet few studies have investigated the relationship between sleep disturbance and clinical trajectory. The Early Detection and Intervention Evaluation (EDIE-2) trial provides longitudinal data on sleep duration and individual psychot...

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Autores principales: Reeve, S., Nickless, A., Sheaves, B., Hodgekins, J., Stewart, S.L.K., Gumley, A., Fowler, D., Morrison, A., Freeman, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publisher B. V 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406020/
https://www.ncbi.nlm.nih.gov/pubmed/30121185
http://dx.doi.org/10.1016/j.schres.2018.08.006
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author Reeve, S.
Nickless, A.
Sheaves, B.
Hodgekins, J.
Stewart, S.L.K.
Gumley, A.
Fowler, D.
Morrison, A.
Freeman, D.
author_facet Reeve, S.
Nickless, A.
Sheaves, B.
Hodgekins, J.
Stewart, S.L.K.
Gumley, A.
Fowler, D.
Morrison, A.
Freeman, D.
author_sort Reeve, S.
collection PubMed
description Sleep disturbance is common among individuals at risk of psychosis, yet few studies have investigated the relationship between sleep disturbance and clinical trajectory. The Early Detection and Intervention Evaluation (EDIE-2) trial provides longitudinal data on sleep duration and individual psychotic experiences from a cohort of individuals at risk of psychosis, which this study utilises in an opportunistic secondary analysis. Shorter and more variable sleep was hypothesised to be associated with more severe psychotic experiences and lower psychological wellbeing. Mixed effect models were used to test sleep duration and range as predictors of individual psychotic experiences and psychological wellbeing over the 12–24 months (with assessments every 3 months) in 160 participants. Shorter sleep duration was associated with more severe delusional ideas and hallucinations cross-sectionally and longitudinally. The longitudinal relationships did not remain significant after conservative controls were added for the previous severity of psychotic experiences. No significant relationships were found between the sleep variables and other psychotic experiences (e.g. cognitive disorganisation), or psychological wellbeing. The results support a relationship between shorter sleep duration and delusional ideas and hallucinations. Future studies should focus on improving sleep disturbance measurement, and test whether treating sleep improves clinical trajectory in the at-risk group.
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spelling pubmed-64060202019-03-21 Sleep duration and psychotic experiences in patients at risk of psychosis: A secondary analysis of the EDIE-2 trial Reeve, S. Nickless, A. Sheaves, B. Hodgekins, J. Stewart, S.L.K. Gumley, A. Fowler, D. Morrison, A. Freeman, D. Schizophr Res Article Sleep disturbance is common among individuals at risk of psychosis, yet few studies have investigated the relationship between sleep disturbance and clinical trajectory. The Early Detection and Intervention Evaluation (EDIE-2) trial provides longitudinal data on sleep duration and individual psychotic experiences from a cohort of individuals at risk of psychosis, which this study utilises in an opportunistic secondary analysis. Shorter and more variable sleep was hypothesised to be associated with more severe psychotic experiences and lower psychological wellbeing. Mixed effect models were used to test sleep duration and range as predictors of individual psychotic experiences and psychological wellbeing over the 12–24 months (with assessments every 3 months) in 160 participants. Shorter sleep duration was associated with more severe delusional ideas and hallucinations cross-sectionally and longitudinally. The longitudinal relationships did not remain significant after conservative controls were added for the previous severity of psychotic experiences. No significant relationships were found between the sleep variables and other psychotic experiences (e.g. cognitive disorganisation), or psychological wellbeing. The results support a relationship between shorter sleep duration and delusional ideas and hallucinations. Future studies should focus on improving sleep disturbance measurement, and test whether treating sleep improves clinical trajectory in the at-risk group. Elsevier Science Publisher B. V 2019-02 /pmc/articles/PMC6406020/ /pubmed/30121185 http://dx.doi.org/10.1016/j.schres.2018.08.006 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Reeve, S.
Nickless, A.
Sheaves, B.
Hodgekins, J.
Stewart, S.L.K.
Gumley, A.
Fowler, D.
Morrison, A.
Freeman, D.
Sleep duration and psychotic experiences in patients at risk of psychosis: A secondary analysis of the EDIE-2 trial
title Sleep duration and psychotic experiences in patients at risk of psychosis: A secondary analysis of the EDIE-2 trial
title_full Sleep duration and psychotic experiences in patients at risk of psychosis: A secondary analysis of the EDIE-2 trial
title_fullStr Sleep duration and psychotic experiences in patients at risk of psychosis: A secondary analysis of the EDIE-2 trial
title_full_unstemmed Sleep duration and psychotic experiences in patients at risk of psychosis: A secondary analysis of the EDIE-2 trial
title_short Sleep duration and psychotic experiences in patients at risk of psychosis: A secondary analysis of the EDIE-2 trial
title_sort sleep duration and psychotic experiences in patients at risk of psychosis: a secondary analysis of the edie-2 trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406020/
https://www.ncbi.nlm.nih.gov/pubmed/30121185
http://dx.doi.org/10.1016/j.schres.2018.08.006
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