First detection of an optrA-positive, linezolid-resistant ST16 Enterococcus faecalis from human in Greece

Until now, in Greece, the resistance of enterococci to linezolid was associated with mutations of domain V of 23S ribosomal RNA (G2576T). Here we report the first linezolid-resistant optrA-positive Enterococcus faecalis sequence type (ST) 16 isolated from a patient with a urinary tract infection (UT...

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Detalles Bibliográficos
Autores principales: Tsilipounidaki, K., Gerontopoulos, A., Papagiannitsis, C., Petinaki, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article(s) from the Special Issue on Infections in Greece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406052/
https://www.ncbi.nlm.nih.gov/pubmed/30899521
http://dx.doi.org/10.1016/j.nmni.2019.01.010
Descripción
Sumario:Until now, in Greece, the resistance of enterococci to linezolid was associated with mutations of domain V of 23S ribosomal RNA (G2576T). Here we report the first linezolid-resistant optrA-positive Enterococcus faecalis sequence type (ST) 16 isolated from a patient with a urinary tract infection (UTI). No travels overseas, contact with food-producing animals or previous treatment with linezolid were reported. Plasmid analysis suggested the chromosomal location of optrA gene. Additionally, whole genome sequencing data revealed the association of optrA with transposon Tn554 and the coexistence with fexA, spc and ermA-like resistance genes. A similar genetic structure has been previously identified in an ST767 E. faecalis from Taiwan.

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