First detection of an optrA-positive, linezolid-resistant ST16 Enterococcus faecalis from human in Greece

Until now, in Greece, the resistance of enterococci to linezolid was associated with mutations of domain V of 23S ribosomal RNA (G2576T). Here we report the first linezolid-resistant optrA-positive Enterococcus faecalis sequence type (ST) 16 isolated from a patient with a urinary tract infection (UT...

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Autores principales: Tsilipounidaki, K., Gerontopoulos, A., Papagiannitsis, C., Petinaki, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article(s) from the Special Issue on Infections in Greece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406052/
https://www.ncbi.nlm.nih.gov/pubmed/30899521
http://dx.doi.org/10.1016/j.nmni.2019.01.010
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author Tsilipounidaki, K.
Gerontopoulos, A.
Papagiannitsis, C.
Petinaki, E.
author_facet Tsilipounidaki, K.
Gerontopoulos, A.
Papagiannitsis, C.
Petinaki, E.
author_sort Tsilipounidaki, K.
collection PubMed
description Until now, in Greece, the resistance of enterococci to linezolid was associated with mutations of domain V of 23S ribosomal RNA (G2576T). Here we report the first linezolid-resistant optrA-positive Enterococcus faecalis sequence type (ST) 16 isolated from a patient with a urinary tract infection (UTI). No travels overseas, contact with food-producing animals or previous treatment with linezolid were reported. Plasmid analysis suggested the chromosomal location of optrA gene. Additionally, whole genome sequencing data revealed the association of optrA with transposon Tn554 and the coexistence with fexA, spc and ermA-like resistance genes. A similar genetic structure has been previously identified in an ST767 E. faecalis from Taiwan.
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spelling pubmed-64060522019-03-21 First detection of an optrA-positive, linezolid-resistant ST16 Enterococcus faecalis from human in Greece Tsilipounidaki, K. Gerontopoulos, A. Papagiannitsis, C. Petinaki, E. New Microbes New Infect Article(s) from the Special Issue on Infections in Greece Until now, in Greece, the resistance of enterococci to linezolid was associated with mutations of domain V of 23S ribosomal RNA (G2576T). Here we report the first linezolid-resistant optrA-positive Enterococcus faecalis sequence type (ST) 16 isolated from a patient with a urinary tract infection (UTI). No travels overseas, contact with food-producing animals or previous treatment with linezolid were reported. Plasmid analysis suggested the chromosomal location of optrA gene. Additionally, whole genome sequencing data revealed the association of optrA with transposon Tn554 and the coexistence with fexA, spc and ermA-like resistance genes. A similar genetic structure has been previously identified in an ST767 E. faecalis from Taiwan. Elsevier 2019-02-07 /pmc/articles/PMC6406052/ /pubmed/30899521 http://dx.doi.org/10.1016/j.nmni.2019.01.010 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article(s) from the Special Issue on Infections in Greece
Tsilipounidaki, K.
Gerontopoulos, A.
Papagiannitsis, C.
Petinaki, E.
First detection of an optrA-positive, linezolid-resistant ST16 Enterococcus faecalis from human in Greece
title First detection of an optrA-positive, linezolid-resistant ST16 Enterococcus faecalis from human in Greece
title_full First detection of an optrA-positive, linezolid-resistant ST16 Enterococcus faecalis from human in Greece
title_fullStr First detection of an optrA-positive, linezolid-resistant ST16 Enterococcus faecalis from human in Greece
title_full_unstemmed First detection of an optrA-positive, linezolid-resistant ST16 Enterococcus faecalis from human in Greece
title_short First detection of an optrA-positive, linezolid-resistant ST16 Enterococcus faecalis from human in Greece
title_sort first detection of an optra-positive, linezolid-resistant st16 enterococcus faecalis from human in greece
topic Article(s) from the Special Issue on Infections in Greece
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406052/
https://www.ncbi.nlm.nih.gov/pubmed/30899521
http://dx.doi.org/10.1016/j.nmni.2019.01.010
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