Why Did COAPT Win While MITRA-FR Failed? Defining the Appropriate Patient Population for MitraClip

In 2018, the world of functional mitral regurgitation changed with the presentation of two trials — Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation (MITRA-FR) and Cardiovascular Outcomes Assessment of the MitraClip Percuta...

Descripción completa

Detalles Bibliográficos
Autores principales: Atianzar, Kimberly, Zhang, Ming, Newhart, Zachary, Gafoor, Sameer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Radcliffe Cardiology 2019
Materias:
Structural
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406127/
https://www.ncbi.nlm.nih.gov/pubmed/30858892
http://dx.doi.org/10.15420/icr.2018.40.1
_version_ 1783401229636861952
author Atianzar, Kimberly
Zhang, Ming
Newhart, Zachary
Gafoor, Sameer
author_facet Atianzar, Kimberly
Zhang, Ming
Newhart, Zachary
Gafoor, Sameer
author_sort Atianzar, Kimberly
collection PubMed
description In 2018, the world of functional mitral regurgitation changed with the presentation of two trials — Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation (MITRA-FR) and Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (COAPT). The trials, which seemed to point in two different directions, raised significant questions for the field. This article looks at the differences in effective regurgitant area, guideline-directed medical therapy, patient selection, technical clues and other reasons why the trials had similar aims but very different findings.
format Online
Article
Text
id pubmed-6406127
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Radcliffe Cardiology
record_format MEDLINE/PubMed
spelling pubmed-64061272019-03-11 Why Did COAPT Win While MITRA-FR Failed? Defining the Appropriate Patient Population for MitraClip Atianzar, Kimberly Zhang, Ming Newhart, Zachary Gafoor, Sameer Interv Cardiol Structural In 2018, the world of functional mitral regurgitation changed with the presentation of two trials — Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation (MITRA-FR) and Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (COAPT). The trials, which seemed to point in two different directions, raised significant questions for the field. This article looks at the differences in effective regurgitant area, guideline-directed medical therapy, patient selection, technical clues and other reasons why the trials had similar aims but very different findings. Radcliffe Cardiology 2019-02 /pmc/articles/PMC6406127/ /pubmed/30858892 http://dx.doi.org/10.15420/icr.2018.40.1 Text en Copyright © 2019, Radcliffe Cardiology https://creativecommons.org/licenses/by-nc/4.0/legalcode This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.
spellingShingle Structural
Atianzar, Kimberly
Zhang, Ming
Newhart, Zachary
Gafoor, Sameer
Why Did COAPT Win While MITRA-FR Failed? Defining the Appropriate Patient Population for MitraClip
title Why Did COAPT Win While MITRA-FR Failed? Defining the Appropriate Patient Population for MitraClip
title_full Why Did COAPT Win While MITRA-FR Failed? Defining the Appropriate Patient Population for MitraClip
title_fullStr Why Did COAPT Win While MITRA-FR Failed? Defining the Appropriate Patient Population for MitraClip
title_full_unstemmed Why Did COAPT Win While MITRA-FR Failed? Defining the Appropriate Patient Population for MitraClip
title_short Why Did COAPT Win While MITRA-FR Failed? Defining the Appropriate Patient Population for MitraClip
title_sort why did coapt win while mitra-fr failed? defining the appropriate patient population for mitraclip
topic Structural
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406127/
https://www.ncbi.nlm.nih.gov/pubmed/30858892
http://dx.doi.org/10.15420/icr.2018.40.1
work_keys_str_mv AT atianzarkimberly whydidcoaptwinwhilemitrafrfaileddefiningtheappropriatepatientpopulationformitraclip
AT zhangming whydidcoaptwinwhilemitrafrfaileddefiningtheappropriatepatientpopulationformitraclip
AT newhartzachary whydidcoaptwinwhilemitrafrfaileddefiningtheappropriatepatientpopulationformitraclip
AT gafoorsameer whydidcoaptwinwhilemitrafrfaileddefiningtheappropriatepatientpopulationformitraclip

Ejemplares similares