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Formin proteins in megakaryocytes and platelets: regulation of actin and microtubule dynamics

The platelet and megakaryocyte cytoskeletons are essential for formation and function of these cells. A dynamic, properly organised tubulin and actin cytoskeleton is critical for the development of the megakaryocyte and the extension of proplatelets. Tubulin in particular plays a pivotal role in the...

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Autores principales: Zuidscherwoude, Malou, Green, Hannah L.H., Thomas, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406210/
https://www.ncbi.nlm.nih.gov/pubmed/29913076
http://dx.doi.org/10.1080/09537104.2018.1481937
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author Zuidscherwoude, Malou
Green, Hannah L.H.
Thomas, Steven G.
author_facet Zuidscherwoude, Malou
Green, Hannah L.H.
Thomas, Steven G.
author_sort Zuidscherwoude, Malou
collection PubMed
description The platelet and megakaryocyte cytoskeletons are essential for formation and function of these cells. A dynamic, properly organised tubulin and actin cytoskeleton is critical for the development of the megakaryocyte and the extension of proplatelets. Tubulin in particular plays a pivotal role in the extension of these proplatelets and the release of platelets from them. Tubulin is further required for the maintenance of platelet size, and actin is the driving force for shape change, spreading and platelet contraction during platelet activation. Whilst several key proteins which regulate these cytoskeletons have been described in detail, the formin family of proteins has received less attention. Formins are intriguing as, although they were initially believed to simply be a nucleator of actin polymerisation, increasing evidence shows they are important regulators of the crosstalk between the actin and microtubule cytoskeletons. In this review, we will introduce the formin proteins and consider the recent evidence that they play an important role in platelets and megakaryocytes in mediating both the actin and tubulin cytoskeletons.
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spelling pubmed-64062102019-03-19 Formin proteins in megakaryocytes and platelets: regulation of actin and microtubule dynamics Zuidscherwoude, Malou Green, Hannah L.H. Thomas, Steven G. Platelets Special Review: Small G Proteins in Platelets The platelet and megakaryocyte cytoskeletons are essential for formation and function of these cells. A dynamic, properly organised tubulin and actin cytoskeleton is critical for the development of the megakaryocyte and the extension of proplatelets. Tubulin in particular plays a pivotal role in the extension of these proplatelets and the release of platelets from them. Tubulin is further required for the maintenance of platelet size, and actin is the driving force for shape change, spreading and platelet contraction during platelet activation. Whilst several key proteins which regulate these cytoskeletons have been described in detail, the formin family of proteins has received less attention. Formins are intriguing as, although they were initially believed to simply be a nucleator of actin polymerisation, increasing evidence shows they are important regulators of the crosstalk between the actin and microtubule cytoskeletons. In this review, we will introduce the formin proteins and consider the recent evidence that they play an important role in platelets and megakaryocytes in mediating both the actin and tubulin cytoskeletons. Taylor & Francis 2018-06-18 /pmc/articles/PMC6406210/ /pubmed/29913076 http://dx.doi.org/10.1080/09537104.2018.1481937 Text en © 2018 Taylor & Francis http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Review: Small G Proteins in Platelets
Zuidscherwoude, Malou
Green, Hannah L.H.
Thomas, Steven G.
Formin proteins in megakaryocytes and platelets: regulation of actin and microtubule dynamics
title Formin proteins in megakaryocytes and platelets: regulation of actin and microtubule dynamics
title_full Formin proteins in megakaryocytes and platelets: regulation of actin and microtubule dynamics
title_fullStr Formin proteins in megakaryocytes and platelets: regulation of actin and microtubule dynamics
title_full_unstemmed Formin proteins in megakaryocytes and platelets: regulation of actin and microtubule dynamics
title_short Formin proteins in megakaryocytes and platelets: regulation of actin and microtubule dynamics
title_sort formin proteins in megakaryocytes and platelets: regulation of actin and microtubule dynamics
topic Special Review: Small G Proteins in Platelets
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406210/
https://www.ncbi.nlm.nih.gov/pubmed/29913076
http://dx.doi.org/10.1080/09537104.2018.1481937
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