Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease

Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions. Interest in AQP4 has increased since it was discovered to be the target antigen in the inflammatory autoimmune disease neuromyeli...

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Detalles Bibliográficos
Autores principales: Mader, Simone, Brimberg, Lior
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406241/
https://www.ncbi.nlm.nih.gov/pubmed/30691235
http://dx.doi.org/10.3390/cells8020090
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author Mader, Simone
Brimberg, Lior
author_facet Mader, Simone
Brimberg, Lior
author_sort Mader, Simone
collection PubMed
description Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions. Interest in AQP4 has increased since it was discovered to be the target antigen in the inflammatory autoimmune disease neuromyelitis optica spectrum disorder (NMOSD). Emerging data suggest that AQP4 may also be implicated in the glymphatic system and may be involved in the clearance of beta-amyloid in Alzheimer’s disease (AD). In this review, we will describe the role of AQP4 in the adult and developing brain as well as its implication for disease.
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spelling pubmed-64062412019-03-19 Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease Mader, Simone Brimberg, Lior Cells Review Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions. Interest in AQP4 has increased since it was discovered to be the target antigen in the inflammatory autoimmune disease neuromyelitis optica spectrum disorder (NMOSD). Emerging data suggest that AQP4 may also be implicated in the glymphatic system and may be involved in the clearance of beta-amyloid in Alzheimer’s disease (AD). In this review, we will describe the role of AQP4 in the adult and developing brain as well as its implication for disease. MDPI 2019-01-27 /pmc/articles/PMC6406241/ /pubmed/30691235 http://dx.doi.org/10.3390/cells8020090 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mader, Simone
Brimberg, Lior
Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease
title Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease
title_full Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease
title_fullStr Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease
title_full_unstemmed Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease
title_short Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease
title_sort aquaporin-4 water channel in the brain and its implication for health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406241/
https://www.ncbi.nlm.nih.gov/pubmed/30691235
http://dx.doi.org/10.3390/cells8020090
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