Cargando…

A Cell-Autonomous Oncosuppressive Role of Human RNASET2 Affecting ECM-Mediated Oncogenic Signaling

RNASET2 is an extracellular ribonuclease endowed with a marked antitumorigenic role in several carcinomas, independent from its catalytic activity. Besides its antitumorigenic role by the recruitment to the tumor mass of immune cells from the monocyte/macrophage lineage, RNASET2 is induced by cellul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roggiani, Francesca, Riva, Cristina, Raspagliesi, Francesco, Porta, Giovanni, Valli, Roberto, Taramelli, Roberto, Acquati, Francesco, Mezzanzanica, Delia, Tomassetti, Antonella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406318/ https://www.ncbi.nlm.nih.gov/pubmed/30813308 http://dx.doi.org/10.3390/cancers11020255

Ejemplares similares

Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis
por: Bruno, Antonino, et al.
Publicado: (2022)

Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase
por: Lualdi, Marta, et al.
Publicado: (2015)

Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells
por: Acquati, Francesco, et al.
Publicado: (2011)

Innate Immune Response Regulation by the Human RNASET2 Tumor Suppressor Gene
por: Acquati, Francesco, et al.
Publicado: (2019)

Guidance of Signaling Activations by Cadherins and Integrins in Epithelial Ovarian Cancer Cells
por: Roggiani, Francesca, et al.
Publicado: (2016)

One-Carbon Metabolism: Biological Players in Epithelial Ovarian Cancer
por: Rizzo, Andrea, et al.
Publicado: (2018)

Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection
por: De Vito, Annarosaria, et al.
Publicado: (2020)

Oncosuppressive functions of decorin
por: Neill, Thomas, et al.
Publicado: (2015)

Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes
por: Marchi, Saverio, et al.
Publicado: (2014)

HvRNASET2 Regulate Connective Tissue and Collagen I Remodeling During Wound Healing Process
por: Baranzini, Nicolò, et al.
Publicado: (2021)

3D Reconstruction of HvRNASET2 Molecule to Understand Its Antibacterial Role
por: Baranzini, Nicolò, et al.
Publicado: (2020)

Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth
por: Rea, Katia, et al.
Publicado: (2018)

Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway
por: Monaci, Sara, et al.
Publicado: (2021)

Resveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and Treatment
por: Xu, Xue-Ling, et al.
Publicado: (2021)

Antimicrobial Role of RNASET2 Protein During Innate Immune Response in the Medicinal Leech Hirudo verbana
por: Baranzini, Nicolò, et al.
Publicado: (2020)

Oncosuppressive Role of RUNX3 in Human Astrocytomas
por: Steponaitis, Giedrius, et al.
Publicado: (2019)

The Oncosuppressive Properties of KCTD1: Its Role in Cell Growth and Mobility
por: Smaldone, Giovanni, et al.
Publicado: (2023)

The Potential Role of the T2 Ribonucleases in TME-Based Cancer Therapy
por: Campomenosi, Paola, et al.
Publicado: (2023)

Oncosuppressive functions of PIDD1 in response to centrosome amplification
por: Vitale, Ilio, et al.
Publicado: (2021)

Spatio-Temporal Changes of Extracellular Matrix (ECM) Stiffness in the Development of the Leech Hirudo verbana
por: Pulze, Laura, et al.
Publicado: (2022)

Choline kinase alpha impairment overcomes TRAIL resistance in ovarian cancer cells
por: Rizzo, Andrea, et al.
Publicado: (2021)

Oncosuppressive role of MicroRNA-205–3p in gastric cancer through inhibition of proliferation and induction of senescence: Oncosuppressive role of MicroRNA-205 in gastric cancer
por: Ma, Xiaoyu, et al.
Publicado: (2021)

Mutations in glioblastoma oncosuppressive pathways pave the way for oncomodulatory activity of cytomegalovirus
por: Hollon, Todd C, et al.
Publicado: (2013)

Expression of Otx Genes in Müller Cells Using an In Vitro Experimental Model of Retinal Hypoxia
por: Azzolini, Claudio, et al.
Publicado: (2021)

Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression
por: Busacca, Sara, et al.
Publicado: (2021)

Decorin‐mediated oncosuppression – a potential future adjuvant therapy for human epithelial cancers
por: Sainio, Annele Orvokki, et al.
Publicado: (2018)

Oncosuppressive miRNAs loaded in lipid nanoparticles potentiate targeted therapies in BRAF-mutant melanoma by inhibiting core escape pathways of resistance
por: Fattore, Luigi, et al.
Publicado: (2022)

Human recombinant RNASET2: A potential anti-cancer drug
por: Roiz, Levava, et al.
Publicado: (2016)

Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2
por: Liu, Peipei, et al.
Publicado: (2017)

RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory
por: Sinkevicius, Kerstin W., et al.
Publicado: (2018)

The frequent and clinically benign anomalies of chromosomes 7 and 20 in Shwachman-diamond syndrome may be subject to further clonal variations
por: Khan, Abdul Waheed, et al.
Publicado: (2021)

Chromosome 6 encoded RNaseT2 protein is a cell growth regulator
por: Liu, Jinglan, et al.
Publicado: (2010)

Molecular characterization and immune modulation properties of Clonorchis sinensis-derived RNASET2
por: Xu, Yanquan, et al.
Publicado: (2013)

Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma
por: Zeng, Zhi, et al.
Publicado: (2020)

Diagnostic and therapeutic potential of RNASET2 in Crohn’s disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion
por: Biener-Ramanujan, Eva, et al.
Publicado: (2022)

Soy diet induces intestinal inflammation in adult Zebrafish: Role of OTX and P53 family
por: Micheloni, Giovanni, et al.
Publicado: (2021)

A Bispecific Antibody to Link a TRAIL-Based Antitumor Approach to Immunotherapy
por: Satta, Alessandro, et al.
Publicado: (2019)

Occurrence of L1M Elements in Chromosomal Rearrangements Associated to Chronic Myeloid Leukemia (CML): Insights from Patient-Specific Breakpoints Characterization
por: L’Abbate, Alberto, et al.
Publicado: (2023)

HTLV-1 Tax directly modulates expression of the CDK6 and RNASET2 genes
por: Polakowski, Nicholas, et al.
Publicado: (2011)

Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2)
por: Huang, Jinliang, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_o9g0dirsla9plpshdc0uim3ppf