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Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer

This study was conducted to investigate the serum levels of membrane-bound mucin 2 (MUC2) in breast cancer (BC) patients and the relationship with tumour progression and known prognostic parameters. We enrolled 127 female patients with histopathologically diagnosed BC who did not receive chemotherap...

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Autores principales: Bademler, Suleyman, Zirtiloglu, Alisan, Sari, Murat, Ucuncu, Muhammed Zubeyr, Dogru, Elif Bilgin, Karabulut, Senem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406351/
https://www.ncbi.nlm.nih.gov/pubmed/30682816
http://dx.doi.org/10.3390/biom9020040
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author Bademler, Suleyman
Zirtiloglu, Alisan
Sari, Murat
Ucuncu, Muhammed Zubeyr
Dogru, Elif Bilgin
Karabulut, Senem
author_facet Bademler, Suleyman
Zirtiloglu, Alisan
Sari, Murat
Ucuncu, Muhammed Zubeyr
Dogru, Elif Bilgin
Karabulut, Senem
author_sort Bademler, Suleyman
collection PubMed
description This study was conducted to investigate the serum levels of membrane-bound mucin 2 (MUC2) in breast cancer (BC) patients and the relationship with tumour progression and known prognostic parameters. We enrolled 127 female patients with histopathologically diagnosed BC who did not receive chemotherapy (CT) or radiotherapy. Serum MUC2 levels were measured by the enzyme-linked immunosorbent assay (ELISA) method and compared with those of 40 age and sex-matched healthy controls. Median age of diagnosis was 50 (range: 26–78). Twenty-eight (22%) patients were metastatic and the most frequent site of metastasis was bone (n = 17, 61%). The median serum MUC2 level of BC patients was significantly higher than that of the controls (198 vs. 54 ng/mL, p < 0.001). There was no significant difference between patients and controls according to known disease-related clinicopathological or laboratory parameters (p > 0.05). Serum MUC2 levels were not associated with survival (p = 0.65). Although serum MUC2 levels might have a diagnostic role, their predictive and prognostic role in survival in BC patients was not detected. Serum levels of MUC2 should be investigated for diagnostic or screening purposes on a larger scale.
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spelling pubmed-64063512019-03-13 Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer Bademler, Suleyman Zirtiloglu, Alisan Sari, Murat Ucuncu, Muhammed Zubeyr Dogru, Elif Bilgin Karabulut, Senem Biomolecules Article This study was conducted to investigate the serum levels of membrane-bound mucin 2 (MUC2) in breast cancer (BC) patients and the relationship with tumour progression and known prognostic parameters. We enrolled 127 female patients with histopathologically diagnosed BC who did not receive chemotherapy (CT) or radiotherapy. Serum MUC2 levels were measured by the enzyme-linked immunosorbent assay (ELISA) method and compared with those of 40 age and sex-matched healthy controls. Median age of diagnosis was 50 (range: 26–78). Twenty-eight (22%) patients were metastatic and the most frequent site of metastasis was bone (n = 17, 61%). The median serum MUC2 level of BC patients was significantly higher than that of the controls (198 vs. 54 ng/mL, p < 0.001). There was no significant difference between patients and controls according to known disease-related clinicopathological or laboratory parameters (p > 0.05). Serum MUC2 levels were not associated with survival (p = 0.65). Although serum MUC2 levels might have a diagnostic role, their predictive and prognostic role in survival in BC patients was not detected. Serum levels of MUC2 should be investigated for diagnostic or screening purposes on a larger scale. MDPI 2019-01-24 /pmc/articles/PMC6406351/ /pubmed/30682816 http://dx.doi.org/10.3390/biom9020040 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bademler, Suleyman
Zirtiloglu, Alisan
Sari, Murat
Ucuncu, Muhammed Zubeyr
Dogru, Elif Bilgin
Karabulut, Senem
Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer
title Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer
title_full Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer
title_fullStr Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer
title_full_unstemmed Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer
title_short Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer
title_sort clinical significance of serum membrane-bound mucin-2 levels in breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406351/
https://www.ncbi.nlm.nih.gov/pubmed/30682816
http://dx.doi.org/10.3390/biom9020040
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