Cargando…

Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism

Acute Myelogenous Leukemia (AML) is a malignant disease of the hematopoietic cells, characterized by impaired differentiation and uncontrolled clonal expansion of myeloid progenitors/precursors, resulting in bone marrow failure and impaired normal hematopoiesis. AML comprises a heterogeneous group o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Castelli, Germana, Pelosi, Elvira, Testa, Ugo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406361/ https://www.ncbi.nlm.nih.gov/pubmed/30813354 http://dx.doi.org/10.3390/cancers11020260

Ejemplares similares

Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy
por: Castelli, Germana, et al.
Publicado: (2017)

CD123 a Therapeutic Target for Acute Myeloid Leukemia and Blastic Plasmocytoid Dendritic Neoplasm
por: Pelosi, Elvira, et al.
Publicado: (2023)

The Growing Role of the BH3 Mimetic Drug Venetoclax in the Therapy of Acute Myeloid Leukemia
por: Pelosi, Elvira, et al.
Publicado: (2022)

Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias
por: Testa, Ugo, et al.
Publicado: (2020)

TP53-Mutated Myelodysplasia and Acute Myeloid Leukemia
por: Testa, Ugo, et al.
Publicado: (2023)

Genetic, Phenotypic, and Clinical Heterogeneity of NPM1-Mutant Acute Myeloid Leukemias
por: Testa, Ugo, et al.
Publicado: (2023)

The Molecular Characterization of Genetic Abnormalities in Esophageal Squamous Cell Carcinoma May Foster the Development of Targeted Therapies
por: Testa, Ugo, et al.
Publicado: (2023)

CD123 as a Therapeutic Target in the Treatment of Hematological Malignancies
por: Testa, Ugo, et al.
Publicado: (2019)

Genetic Alterations in Renal Cancers: Identification of The Mechanisms Underlying Cancer Initiation and Progression and of Therapeutic Targets
por: Testa, Ugo, et al.
Publicado: (2020)

Colorectal Cancer: Genetic Abnormalities, Tumor Progression, Tumor Heterogeneity, Clonal Evolution and Tumor-Initiating Cells
por: Testa, Ugo, et al.
Publicado: (2018)

Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells
por: Testa, Ugo, et al.
Publicado: (2018)

Esophageal Cancer: Genomic and Molecular Characterization, Stem Cell Compartment and Clonal Evolution
por: Testa, Ugo, et al.
Publicado: (2017)

Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells
por: Castelli, Germana, et al.
Publicado: (2017)

Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells
por: Pelosi, Elvira, et al.
Publicado: (2017)

Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells
por: Testa, Ugo, et al.
Publicado: (2017)

Genetic Abnormalities, Clonal Evolution, and Cancer Stem Cells of Brain Tumors
por: Testa, Ugo, et al.
Publicado: (2018)

Genetic Alterations of Metastatic Colorectal Cancer
por: Testa, Ugo, et al.
Publicado: (2020)

Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications
por: Testa, Ugo, et al.
Publicado: (2019)

Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments
por: Testa, Ugo, et al.
Publicado: (2020)

Clonal Hematopoiesis: Role in Hematologic and Non-Hematologic Malignancies
por: Testa, Ugo, et al.
Publicado: (2022)

CAR-T Cell Therapy in Large B Cell Lymphoma
por: Testa, Ugo, et al.
Publicado: (2023)

miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development
por: Testa, Ugo, et al.
Publicado: (2017)

The Impact of FLT3 Mutations on the Development of Acute Myeloid Leukemias
por: Testa, Ugo, et al.
Publicado: (2013)

Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells
por: Testa, Ugo, et al.
Publicado: (2018)

The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells
por: Spinello, Isabella, et al.
Publicado: (2019)

Targeting Lactate Metabolism by Inhibiting MCT1 or MCT4 Impairs Leukemic Cell Proliferation, Induces Two Different Related Death-Pathways and Increases Chemotherapeutic Sensitivity of Acute Myeloid Leukemia Cells
por: Saulle, Ernestina, et al.
Publicado: (2021)

CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies
por: Testa, Ugo, et al.
Publicado: (2014)

High-dose ascorbate and arsenic trioxide selectively kill acute myeloid leukemia and acute promyelocytic leukemia blasts in vitro
por: Noguera, Nélida I., et al.
Publicado: (2017)

Mitochondrial metabolism as a target for acute myeloid leukemia treatment
por: Panina, Svetlana B., et al.
Publicado: (2021)

Autocrine Role of Angiopoietins during Megakaryocytic Differentiation
por: Saulle, Ernestina, et al.
Publicado: (2012)

Emerging approaches to target mitochondrial apoptosis in cancer cells
por: Gilmore, Andrew, et al.
Publicado: (2019)

New and Emerging Targeted Therapies for Pediatric Acute Myeloid Leukemia (AML)
por: Chen, Jing, et al.
Publicado: (2020)

Emerging Targeted Therapy for Specific Genomic Abnormalities in Acute Myeloid Leukemia
por: Chi, Sung-Gi, et al.
Publicado: (2022)

Pediatric Acute Lymphoblastic Leukemia Emerging Therapies—From Pathway to Target
por: Ivanov, Anca Viorica, et al.
Publicado: (2023)

The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism
por: Stuhldreier, Fabian, et al.
Publicado: (2022)

Emerging therapies for acute myeloid leukemia
por: Saygin, Caner, et al.
Publicado: (2017)

Targeting metabolic vulnerabilities to overcome resistance to therapy in acute myeloid leukemia
por: Sharma, Priyanka, et al.
Publicado: (2023)

Ex Vivo Anti-Leukemic Effect of Exosome-like Grapefruit-Derived Nanovesicles from Organic Farming—The Potential Role of Ascorbic Acid
por: Castelli, Germana, et al.
Publicado: (2023)

Targeting Metabolic Reprogramming in Acute Myeloid Leukemia
por: Castro, Isabel, et al.
Publicado: (2019)

Advances in targeted therapy for acute myeloid leukemia
por: Yu, Jifeng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_c4ab0qlgs9am0qlt4ohb4oop6i