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The Enigmatic Protein Kinase C-eta
Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406448/ https://www.ncbi.nlm.nih.gov/pubmed/30781807 http://dx.doi.org/10.3390/cancers11020214 |
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author | Basu, Alakananda |
author_facet | Basu, Alakananda |
author_sort | Basu, Alakananda |
collection | PubMed |
description | Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death. It was also shown to contribute to chemoresistance in several cancers. PKCη has been associated with several cancers, including renal cell carcinoma, glioblastoma, breast cancer, non-small cell lung cancer, and acute myeloid leukemia. However, mice lacking PKCη were more susceptible to tumor formation in a two-stage carcinogenesis model, and it is downregulated in hepatocellular carcinoma. Thus, the role of PKCη in cancer remains controversial. The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer. |
format | Online Article Text |
id | pubmed-6406448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64064482019-03-21 The Enigmatic Protein Kinase C-eta Basu, Alakananda Cancers (Basel) Review Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death. It was also shown to contribute to chemoresistance in several cancers. PKCη has been associated with several cancers, including renal cell carcinoma, glioblastoma, breast cancer, non-small cell lung cancer, and acute myeloid leukemia. However, mice lacking PKCη were more susceptible to tumor formation in a two-stage carcinogenesis model, and it is downregulated in hepatocellular carcinoma. Thus, the role of PKCη in cancer remains controversial. The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer. MDPI 2019-02-13 /pmc/articles/PMC6406448/ /pubmed/30781807 http://dx.doi.org/10.3390/cancers11020214 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Basu, Alakananda The Enigmatic Protein Kinase C-eta |
title | The Enigmatic Protein Kinase C-eta |
title_full | The Enigmatic Protein Kinase C-eta |
title_fullStr | The Enigmatic Protein Kinase C-eta |
title_full_unstemmed | The Enigmatic Protein Kinase C-eta |
title_short | The Enigmatic Protein Kinase C-eta |
title_sort | enigmatic protein kinase c-eta |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406448/ https://www.ncbi.nlm.nih.gov/pubmed/30781807 http://dx.doi.org/10.3390/cancers11020214 |
work_keys_str_mv | AT basualakananda theenigmaticproteinkinaseceta AT basualakananda enigmaticproteinkinaseceta |