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The Enigmatic Protein Kinase C-eta

Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and...

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Detalles Bibliográficos
Autor principal: Basu, Alakananda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406448/
https://www.ncbi.nlm.nih.gov/pubmed/30781807
http://dx.doi.org/10.3390/cancers11020214
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author Basu, Alakananda
author_facet Basu, Alakananda
author_sort Basu, Alakananda
collection PubMed
description Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death. It was also shown to contribute to chemoresistance in several cancers. PKCη has been associated with several cancers, including renal cell carcinoma, glioblastoma, breast cancer, non-small cell lung cancer, and acute myeloid leukemia. However, mice lacking PKCη were more susceptible to tumor formation in a two-stage carcinogenesis model, and it is downregulated in hepatocellular carcinoma. Thus, the role of PKCη in cancer remains controversial. The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer.
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spelling pubmed-64064482019-03-21 The Enigmatic Protein Kinase C-eta Basu, Alakananda Cancers (Basel) Review Protein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death. It was also shown to contribute to chemoresistance in several cancers. PKCη has been associated with several cancers, including renal cell carcinoma, glioblastoma, breast cancer, non-small cell lung cancer, and acute myeloid leukemia. However, mice lacking PKCη were more susceptible to tumor formation in a two-stage carcinogenesis model, and it is downregulated in hepatocellular carcinoma. Thus, the role of PKCη in cancer remains controversial. The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer. MDPI 2019-02-13 /pmc/articles/PMC6406448/ /pubmed/30781807 http://dx.doi.org/10.3390/cancers11020214 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Basu, Alakananda
The Enigmatic Protein Kinase C-eta
title The Enigmatic Protein Kinase C-eta
title_full The Enigmatic Protein Kinase C-eta
title_fullStr The Enigmatic Protein Kinase C-eta
title_full_unstemmed The Enigmatic Protein Kinase C-eta
title_short The Enigmatic Protein Kinase C-eta
title_sort enigmatic protein kinase c-eta
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406448/
https://www.ncbi.nlm.nih.gov/pubmed/30781807
http://dx.doi.org/10.3390/cancers11020214
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