Targeted Radionuclide Therapy: New Advances for Improvement of Patient Management and Response

Compared to external beam radiotherapy, targeted radionuclide therapy (TRT) allows for systemic radiation treatment of metastatic lesions. Published work on recent strategies to improve patient management and response to TRT through individualising patient treatment, modifying treatment pharmacokine...

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Detalles Bibliográficos
Autores principales: Malcolm, Javian, Falzone, Nadia, Lee, Boon Q., Vallis, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406485/
https://www.ncbi.nlm.nih.gov/pubmed/30823564
http://dx.doi.org/10.3390/cancers11020268
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author Malcolm, Javian
Falzone, Nadia
Lee, Boon Q.
Vallis, Katherine A.
author_facet Malcolm, Javian
Falzone, Nadia
Lee, Boon Q.
Vallis, Katherine A.
author_sort Malcolm, Javian
collection PubMed
description Compared to external beam radiotherapy, targeted radionuclide therapy (TRT) allows for systemic radiation treatment of metastatic lesions. Published work on recent strategies to improve patient management and response to TRT through individualising patient treatment, modifying treatment pharmacokinetics and increasing anticancer potency are discussed in this review, with a special focus on the application of clinically evaluated radiolabelled ligands and peptides in the treatment of neuroendocrine and prostate cancers.
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spelling pubmed-64064852019-03-21 Targeted Radionuclide Therapy: New Advances for Improvement of Patient Management and Response Malcolm, Javian Falzone, Nadia Lee, Boon Q. Vallis, Katherine A. Cancers (Basel) Review Compared to external beam radiotherapy, targeted radionuclide therapy (TRT) allows for systemic radiation treatment of metastatic lesions. Published work on recent strategies to improve patient management and response to TRT through individualising patient treatment, modifying treatment pharmacokinetics and increasing anticancer potency are discussed in this review, with a special focus on the application of clinically evaluated radiolabelled ligands and peptides in the treatment of neuroendocrine and prostate cancers. MDPI 2019-02-25 /pmc/articles/PMC6406485/ /pubmed/30823564 http://dx.doi.org/10.3390/cancers11020268 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Malcolm, Javian
Falzone, Nadia
Lee, Boon Q.
Vallis, Katherine A.
Targeted Radionuclide Therapy: New Advances for Improvement of Patient Management and Response
title Targeted Radionuclide Therapy: New Advances for Improvement of Patient Management and Response
title_full Targeted Radionuclide Therapy: New Advances for Improvement of Patient Management and Response
title_fullStr Targeted Radionuclide Therapy: New Advances for Improvement of Patient Management and Response
title_full_unstemmed Targeted Radionuclide Therapy: New Advances for Improvement of Patient Management and Response
title_short Targeted Radionuclide Therapy: New Advances for Improvement of Patient Management and Response
title_sort targeted radionuclide therapy: new advances for improvement of patient management and response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406485/
https://www.ncbi.nlm.nih.gov/pubmed/30823564
http://dx.doi.org/10.3390/cancers11020268
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