Antimicrobial Peptide TP4 Induces ROS-Mediated Necrosis by Triggering Mitochondrial Dysfunction in Wild-Type and Mutant p53 Glioblastoma Cells

Antimicrobial peptide tilapia piscidin 4 (TP4) from Oreochromis niloticus exhibits potent bactericidal and anti-tumorigenic effects. In a variety of cancers, the mutation status of p53 is a decisive factor for therapeutic sensitivity. Therefore, we investigated the impact of p53 status on TP4-induce...

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Detalles Bibliográficos
Autores principales: Su, Bor-Chyuan, Pan, Chieh-Yu, Chen, Jyh-Yih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406555/
https://www.ncbi.nlm.nih.gov/pubmed/30717309
http://dx.doi.org/10.3390/cancers11020171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406555/
https://www.ncbi.nlm.nih.gov/pubmed/30717309
http://dx.doi.org/10.3390/cancers11020171

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