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Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species

Hydrogen sulfide (H(2)S/HS(–)) can be formed in mammalian tissues and exert physiological effects. It can react with metal centers and oxidized thiol products such as disulfides (RSSR) and sulfenic acids (RSOH). Reactions with oxidized thiol products form persulfides (RSSH/RSS(–)). Persulfides have...

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Autores principales: Benchoam, Dayana, Cuevasanta, Ernesto, Möller, Matías N., Alvarez, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406583/
https://www.ncbi.nlm.nih.gov/pubmed/30813248
http://dx.doi.org/10.3390/antiox8020048
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author Benchoam, Dayana
Cuevasanta, Ernesto
Möller, Matías N.
Alvarez, Beatriz
author_facet Benchoam, Dayana
Cuevasanta, Ernesto
Möller, Matías N.
Alvarez, Beatriz
author_sort Benchoam, Dayana
collection PubMed
description Hydrogen sulfide (H(2)S/HS(–)) can be formed in mammalian tissues and exert physiological effects. It can react with metal centers and oxidized thiol products such as disulfides (RSSR) and sulfenic acids (RSOH). Reactions with oxidized thiol products form persulfides (RSSH/RSS(–)). Persulfides have been proposed to transduce the signaling effects of H(2)S through the modification of critical cysteines. They are more nucleophilic and acidic than thiols and, contrary to thiols, also possess electrophilic character. In this review, we summarize the biochemistry of hydrogen sulfide and persulfides, focusing on redox aspects. We describe biologically relevant one- and two-electron oxidants and their reactions with H(2)S and persulfides, as well as the fates of the oxidation products. The biological implications are discussed.
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spelling pubmed-64065832019-03-08 Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species Benchoam, Dayana Cuevasanta, Ernesto Möller, Matías N. Alvarez, Beatriz Antioxidants (Basel) Review Hydrogen sulfide (H(2)S/HS(–)) can be formed in mammalian tissues and exert physiological effects. It can react with metal centers and oxidized thiol products such as disulfides (RSSR) and sulfenic acids (RSOH). Reactions with oxidized thiol products form persulfides (RSSH/RSS(–)). Persulfides have been proposed to transduce the signaling effects of H(2)S through the modification of critical cysteines. They are more nucleophilic and acidic than thiols and, contrary to thiols, also possess electrophilic character. In this review, we summarize the biochemistry of hydrogen sulfide and persulfides, focusing on redox aspects. We describe biologically relevant one- and two-electron oxidants and their reactions with H(2)S and persulfides, as well as the fates of the oxidation products. The biological implications are discussed. MDPI 2019-02-22 /pmc/articles/PMC6406583/ /pubmed/30813248 http://dx.doi.org/10.3390/antiox8020048 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Benchoam, Dayana
Cuevasanta, Ernesto
Möller, Matías N.
Alvarez, Beatriz
Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species
title Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species
title_full Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species
title_fullStr Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species
title_full_unstemmed Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species
title_short Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species
title_sort hydrogen sulfide and persulfides oxidation by biologically relevant oxidizing species
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406583/
https://www.ncbi.nlm.nih.gov/pubmed/30813248
http://dx.doi.org/10.3390/antiox8020048
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