Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma

Hedgehog (Hh) signaling is a critical developmental regulator and its aberrant activation, due to somatic or germline mutations of genes encoding pathway components, causes Basal Cell Carcinoma (BCC) and medulloblastoma (MB). A growing effort has been devoted at the identification of druggable vulne...

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Detalles Bibliográficos
Autores principales: Coni, Sonia, Di Magno, Laura, Serrao, Silvia Maria, Kanamori, Yuta, Agostinelli, Enzo, Canettieri, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406590/
https://www.ncbi.nlm.nih.gov/pubmed/30754726
http://dx.doi.org/10.3390/cells8020150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406590/
https://www.ncbi.nlm.nih.gov/pubmed/30754726
http://dx.doi.org/10.3390/cells8020150

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