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Discrepancies in Persistent Dry Eye Signs and Symptoms in Bilateral Pseudophakic Patients

Despite the increased awareness of early prophylaxis and treatment for dry eye disease (DED) during the first few weeks after cataract surgery, the chronic effect of cataract surgery on the risk of ocular surface abnormalities has not been fully explored. This study was to assess the prevalence of D...

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Autores principales: Hanyuda, Akiko, Ayaki, Masahiko, Tsubota, Kazuo, Negishi, Kazuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406599/
https://www.ncbi.nlm.nih.gov/pubmed/30736453
http://dx.doi.org/10.3390/jcm8020211
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author Hanyuda, Akiko
Ayaki, Masahiko
Tsubota, Kazuo
Negishi, Kazuno
author_facet Hanyuda, Akiko
Ayaki, Masahiko
Tsubota, Kazuo
Negishi, Kazuno
author_sort Hanyuda, Akiko
collection PubMed
description Despite the increased awareness of early prophylaxis and treatment for dry eye disease (DED) during the first few weeks after cataract surgery, the chronic effect of cataract surgery on the risk of ocular surface abnormalities has not been fully explored. This study was to assess the prevalence of DE subjective symptoms and clinical tests according to the cataract surgery. A total of 172 patients who underwent bilateral cataract surgeries at least 5 months before the recruitment date and 1225 controls with no cataracts were evaluated for their subjective DE symptoms (dry sensation, foreign-body sensation, ocular pain, ocular fatigue, sensitivity to bright light, and blurred vision) and ophthalmic parameters (tear break-up time, keratoconjunctival staining scores, and maximum blinking interval). The presence of subjective DE symptoms was generally inversely associated with cataract surgeries, whereas abnormal clinical tests were more pronounced among postsurgical cataract patients than among controls. Pseudophakic patients showed a 57% increased prevalence of severe keratoconjunctivitis, compared to controls (P = 0.02). In contrast, among subjective DE symptoms, significantly lower odds of sensitivity to bright light were detected among cases than controls; the multivariable-adjusted odds ratio (95% confidence interval) comparing pseudophakic patients with noncataract patients was 0.56 (0.34–0.92) (P = 0.02). In conclusion, persistent tear instability and corneal epitheliopathy were found even at several months or more after cataract surgery. This study demonstrates the importance of evaluating ocular surface conditions in pseudophakic patients, even if they lack DE symptoms.
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spelling pubmed-64065992019-03-22 Discrepancies in Persistent Dry Eye Signs and Symptoms in Bilateral Pseudophakic Patients Hanyuda, Akiko Ayaki, Masahiko Tsubota, Kazuo Negishi, Kazuno J Clin Med Article Despite the increased awareness of early prophylaxis and treatment for dry eye disease (DED) during the first few weeks after cataract surgery, the chronic effect of cataract surgery on the risk of ocular surface abnormalities has not been fully explored. This study was to assess the prevalence of DE subjective symptoms and clinical tests according to the cataract surgery. A total of 172 patients who underwent bilateral cataract surgeries at least 5 months before the recruitment date and 1225 controls with no cataracts were evaluated for their subjective DE symptoms (dry sensation, foreign-body sensation, ocular pain, ocular fatigue, sensitivity to bright light, and blurred vision) and ophthalmic parameters (tear break-up time, keratoconjunctival staining scores, and maximum blinking interval). The presence of subjective DE symptoms was generally inversely associated with cataract surgeries, whereas abnormal clinical tests were more pronounced among postsurgical cataract patients than among controls. Pseudophakic patients showed a 57% increased prevalence of severe keratoconjunctivitis, compared to controls (P = 0.02). In contrast, among subjective DE symptoms, significantly lower odds of sensitivity to bright light were detected among cases than controls; the multivariable-adjusted odds ratio (95% confidence interval) comparing pseudophakic patients with noncataract patients was 0.56 (0.34–0.92) (P = 0.02). In conclusion, persistent tear instability and corneal epitheliopathy were found even at several months or more after cataract surgery. This study demonstrates the importance of evaluating ocular surface conditions in pseudophakic patients, even if they lack DE symptoms. MDPI 2019-02-07 /pmc/articles/PMC6406599/ /pubmed/30736453 http://dx.doi.org/10.3390/jcm8020211 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hanyuda, Akiko
Ayaki, Masahiko
Tsubota, Kazuo
Negishi, Kazuno
Discrepancies in Persistent Dry Eye Signs and Symptoms in Bilateral Pseudophakic Patients
title Discrepancies in Persistent Dry Eye Signs and Symptoms in Bilateral Pseudophakic Patients
title_full Discrepancies in Persistent Dry Eye Signs and Symptoms in Bilateral Pseudophakic Patients
title_fullStr Discrepancies in Persistent Dry Eye Signs and Symptoms in Bilateral Pseudophakic Patients
title_full_unstemmed Discrepancies in Persistent Dry Eye Signs and Symptoms in Bilateral Pseudophakic Patients
title_short Discrepancies in Persistent Dry Eye Signs and Symptoms in Bilateral Pseudophakic Patients
title_sort discrepancies in persistent dry eye signs and symptoms in bilateral pseudophakic patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406599/
https://www.ncbi.nlm.nih.gov/pubmed/30736453
http://dx.doi.org/10.3390/jcm8020211
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